The world number two, though, missed a golden birdie chance at the 17th, and despite making his birdie on 18, Appleby's safe par clinched victory.
Then Cabrera's putt stopped on the edge of the cup, setting up Scott's chance for a winning birdie.
Jason Kokrak needed a birdie on the 18th to have any chance at a playoff and yanked his tee shot into the water.
Standing four-over on the par-five17th, the U.S. PGA champion needed a birdie or better to get stand a chance of making the final two rounds.
All three players then parred the 18th, the opening play-off hole, before Campbell bowed out at the 17th where McNeill had a chance of victory, only to miss a birdie putt from 20-feet.
But he made the green in two at 17 to make the birdie that ensured his presence for the weekend - and another chance of the good night's sleep (and a touch of medication) he needs to shake of a heavy cold.
That gave Choi one last chance to even the score on the 18th, but she pulled her birdie putt wide by an inch.
Runner-up Reid, the Tour's leading rookie, had the chance to force a play-off but missed a five-foot birdie putt at the last as she carded a 73.
The Queenslander gave himself the chance to draw level with his second at the 449-yard par four but his birdie putt swung to the right of the cup.
That gave Londoner Wall a chance to tie for second and he did it in dramatic fashion with a 35-foot birdie putt - one which qualifies him for the Open at Hoylake in two weeks' time.
Weekley's 22-foot eagle chance at No. 1 stopped about 6 inches from the cup before he chipped in for another birdie from behind the third green.
Couples, 46, lost his chance when he failed to get up and down from sand at the 16th and then failed to birdie the long 17th downwind.
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