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This of course depends only on the frequency of the binding sites in the genome.
ECONOMIST: How (and why) to find a needle in a haystack | The
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In doing so, he has already discovered several binding sites that no one knew were there.
ECONOMIST: How (and why) to find a needle in a haystack | The
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It allows him to design novel binding sites that will contain enough information.
ECONOMIST: How (and why) to find a needle in a haystack | The
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Recently, however, Carlos Bustamante, a biophysicist at the Howard Hughes Medical Institute at the University of Oregon, in Eugene, and his colleagues there and at the University of California, Santa Barbara, have found a way to observe proteins as they search for their binding sites.
ECONOMIST: How (and why) to find a needle in a haystack | The
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After scanning across the whole surface, having previously compiled a relief map of the surface in the usual way, the researchers were able to draw up a map of the binding sites and pinpoint the positions of the antigens to within two or three nanometres.
ECONOMIST: Microscopy
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This second kind of analysis is done by lining up lots of known binding sites for a particular protein, comparing them position by position, and so finding out which letter is most likely to occur at which position, and how probable it is that a different letter may sometimes crop up instead.
ECONOMIST: How (and why) to find a needle in a haystack | The