But in 2009, some of the big ones rose like a hot air balloon.
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Shunsuke Nakamura flighted the ball into a busy six-yard box and the big Dutchman rose highest to flick the ball past Zaluska.
The big defender rose to guide a header across the six yard box, and McArthur bundled the ball in with the use of an arm.
Big biotechs rose from 4 percent to 10 percent, while specialty pharma rose from 2 percent to 15 percent, and generics climbed from 8 percent to 16 percent.
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Last year, big biotech firepower rose 61 percent relative to 2006, thanks to premium product pricing and a lack of generic competition.
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The ACC will send either Florida State or Georgia Tech to the Orange Bowl, the Big Ten will have Nebraska or Wisconsin in the Rose Bowl and the Big 12 will be represented in the Fiesta Bowl by Kansas State or Oklahoma depending on how their games play out this weekend.
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The Dow Jones Titans Bank index, which tracks big banks worldwide, rose 1.4%.
It seems that despite enthusiasm about the direction of the market as a whole, for many investors the bloom is coming off the rose for big banks.
Last year the number of alliances between big pharma and biotech rose to 502, from just 69 in 1993, according to Deloitte's "Critical Factors for Alliance Formation" report, released Sunday.
But by January 2010, the bloom had begun to come off the rose in a big way.
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The just-completed interleague series between the Yankees and Reds in Cincinnati probably had some people reflecting on the 1976 World Series, when the Bombers were swept out in four straight by the Big Red Machine of Pete Rose, Joe Morgan and Johnny Bench.
On the big day she wore a pale rose-coloured dress adorned with a huge bow on her left shoulder.
On the other hand, its growth in the 1990s reflected a big improvement in productivity, which rose by over 2% a year in the 1990s.
According to the Halifax, a big mortgage lender, house prices rose by 13.6% in the year to December, the fastest increase since the late 1980s boom.
But still: Entering Monday night's Wisconsin-Oregon Rose Bowl, the Big Ten stood 33-51 in bowl games since 2000, 3-5 this season, 1-3 on the sport's showcase bowl day.
In the absence of the Ivory Coast defender and the big striker, Celtic defender Daniel Majstorovic rose above the visiting defence to meet a couple of corners without finding the target with his headers.
No. 11 Michigan State and No. 15 Wisconsin were playing for the Big Ten title and a spot in the Rose Bowl in Indianapolis.
With three minutes left, Carroll rose into the London sky with big-bodied opponent Marouane Fellaini all over him, met Craig Bellamy's free kick and headed it past Everton goalkeeper Tim Howard.
Bachman and others might be pleased to see the Rose Bowl preserved, but the Big 12 and SEC would be even happier to take the top recruits and have Ohio State and USC come begging for an invite.
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Madagascar saw a big fall in mortality but levels of poor nutrition rose.
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After the Plaza accord between the big industrial countries in 1985, the Japanese yen rose by 80% against the dollar in three years.
As player salaries rose, and the gulf widened between big market and small market clubs, owners turned increasingly to adminstrative types to run their clubs.
In effect, many of the big banks have turned themselves from businesses whose profits rose and fell with the capital-raising needs of their clients into immense trading houses whose fortunes depend on their ability to exploit day-to-day movements in the markets.
That was despite a big boost to bicycle sales in the summer, which rose on the back of the popularity of cycling during the London Olympics.
"You might have 50, 000 chickens in the barn, and no idea which one laid the big egg, " says Marcus Rust, CEO of Rose Acre Farms, in Seymour, Ind.
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As foreclosures rose, banks and hedge funds that had invested big in subprime mortgages were weighed down by worthless assets.
Last season, TCU defeated Wisconsin in the Rose Bowl, the traditional postseason home of the Big Ten and Pac-10's top teams.
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This has been a thorny business in recent years: Big Ten teams have won exactly one of the last 12 Rose Bowls.
It isn't quite Rose Bowl season yet, but on Saturday, Big Ten teams went belly-up once more against the Pac-12: a perfect 0-3.
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