Not too long ago, the idea that big-shot American CEOs would be touting Mexico would have seemed unlikely.

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The Celldex drug, undeniably a long-shot, would be a big deal for brain cancer patients if it works.

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If they win that long shot argument, it would be a very big deal.

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He was considered a long shot to even stick in the league, and big time player agents, noting the lack of star quality needed to appeal to national advertisers, weren't clamoring after him.

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Played long off the tee, but it's a big advantage going into the greens with the second shot.

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Intel's participation in Comcast's Reference Design Kit program is also referenced, although given Big Cable's traditional reluctance regarding alternative delivery models, any sort of tie-in here seems like a long shot to us.

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