Brokerage houses were among the big losers in early trading on U.S. exchanges.
We focus on PARC because that happened to work out, but HP for instance, made major early Next Big Thing bets on hand-held calculators for the exact same reasons.
Any scoring Michigan gets from either is a bonus, but on this night, those points early on were big.
Employers also need to decide early on how big a threat to their staff would force them to withdraw.
In practice, they accept special offers to members of a loyalty club, or to people who book tickets early or keep a big balance on an account.
We are in the early years of a big experiment centered on using hundreds of millions of consumers and activists to pursue progressive social ends.
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Early in the week there was big news on the Dell buyout.
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It's our chance to get in early on a brand that will be big.
Big prints in weekly calls on VLO in the early going this morning suggests some traders are positioning for the price of the underlying to extend gains in the near term.
The largest crowd ever for a women's game at West Virginia saw Griner finish with 28 points, 10 rebounds and 10 blocked shots, and the Lady Bears built a big early lead in defeating the Mountaineers 80-49 on Saturday night.
Caterpillar was having a more mixed impact on the Dow, providing a big lift early in the day before wobbling.
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As illustrated on the chart, an early morning big decline was triggered by the release of housing and economic data.
Instead of spreading his bets and taking profits early like most venture capitalists, Kirk bets big on a few small companies and stays the course until a product gets to market.
John Paulson, the hedge fund manager who minted billions by shorting the mortgage market (apparently with the help of Goldman Sachs), was also big-time short on the broker-dealers as early as January 2007.
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"Early on, we recognized that they put a big man on me, " Shumpert said.
Goingconcern is a site that discusses the woes of accountants in the early stages of their career with a focus on the Big Four.
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In 1998 Parrot Cay debuted, on a tiny, private cay accessible only by boat, and early in 2005, The Palms resort on the "big" island of Providenciales (population: 6, 000) opened, promoting its spa as its centerpiece.
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So it's time for Pfizer to end the denial, start the mourning--early, while Lipitor is still generating big sales--and move on.
Back home, thousands of fans have gathered in the early hours of the morning to watch their new heroes on big screens.
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"While Mitt Romney and his allies are counting on big ad buys ... we've made early investments in battleground states -- where we've been registering folks and keeping an open conversation going with undecided voters for months -- to build an historic grassroots organization that will pay off when the votes are counted, " Obama campaign spokesman Adam Fetcher said.
Spies dropped from second early in the race, which was a big blow after qualifying in fourth on Saturday.
Averting such a disaster will take big changes: more people contributing, less generous pensions and a ban on early retirement.
The recent housing bubble popped early in California and a wave of home foreclosures has taken a big toll on cities there.
The result is a very big inventory of early stage consumer web companies out there, looking for follow-on financing, strategic deals, customers, and exits.
The number of artist profiles tracked by Next Big Sound on Twitter has also risen, by close to 260 percent from early 2011 to now.
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The how-to-get-there-from-here stuff will have to be dealt with, in time, but focusing on it too early makes it too hard to truly Think Big.
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And once they get out, usually due to painful losses, they tend to stay away from another relationship with the market for very long periods, like those who have been on the sidelines since the big bear market plunge of 2008 and early last year, not enticed back in for even part of the new bull market that began early last year.
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But this year, young voters made up their minds early on, and the astronomical levels of support for Obama made a big difference in the primaries and make a big difference in the general election.
Presuming they can deliver on their promises (a very big 'if' when it comes to early stage technologies), the companies in the competition had plenty of "wow technology" to go around.
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