The injury is a big blow for the team with the worst record in the majors.
It is also a big blow for British hopes of staging the 2012 Olympics.
Ibiden's success has been a big blow to Kyocera, but the contest is just beginning.
Failure to liberalise farm trade would be a big blow to the poor world.
But London 2012 spokesman Adrian Bassett added that the change was "not a big blow".
But on November 2nd a big blow could be struck against the ancient practice of gerrymandering.
This was a big blow to libraries, which consider lending current bestsellers to be a critical service.
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Verizon is not going to countenance the big blow to its U.S. market share without a response.
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"It's a big blow for us as we'll miss Phil for the rest of the season, " Melville added.
Peugeot are laying off 8, 000 workers and closing one auto assemble pan, a big blow to French prestige.
This is a big blow: Maersk accounts for 25% of Charleston's container volume.
Spies dropped from second early in the race, which was a big blow after qualifying in fourth on Saturday.
David Warr, from the Chamber of Commerce, said the firm's decision to scrap the plan was a "big blow".
This has dealt a big blow to businesses that rely on part-timers, such as shops, restaurants, hotels and hairdressers.
About 110, 000 automotive jobs are likely to be lost this year a big blow to a nation of 44 million.
Correspondents say the decision will come as a big blow to Indian wrestlers who have been making a mark internationally.
Supplanting Google's popular maps on its millions of mobile devices would be a big blow in the rivals' ongoing slugfest.
Replacements are expected to cost millions, a "big, big blow" for the financially struggling museum, said Susan Henshaw Jones, the museum's director.
Losing there would have been a big blow to the opposition's morale.
Nonetheless, the respect he commands on Capitol Hill, particularly among Republicans, means his comments are a big blow to the White House.
"The likelihood is he will be out for about six months which is a big blow for Sam, " said Bolton boss Owen Coyle.
About 110, 000 jobs are likely to be lost at automakers and suppliers this year a big blow to a nation of 44 million.
"It would be a very big blow to England and it's a blow for us because he's a very good player, " he added.
The Braves scored three runs off Yankees starter David Phelps in the fifth inning, the big blow a two-run homer by Juan Francisco.
But the effect is to make India the sixth member of the nuclear club, and that's a big blow to the cause of non-proliferation.
But it was Wright, a six-time All-Star and the fourth team captain in franchise history, who delivered the big blow that stirred the Mets' dugout.
That would be a big blow to the cause of free trade, argues William Cornish, a specialist in intellectual property at the University of Cambridge.
The next big blow to the tobacco industry came in the early 1960s, with the formation of the Surgeon General's Advisory Committee on Smoking and Health.
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