It will be an especially important meeting for Pfizer , which makes Celebrex and Bextra.
Then he did back-of-the-envelope calculations that assembled the available data on Celebrex, Bextra and Vioxx.
In April it said Vioxx could not return and also requested that Pfizer pull Bextra.
Many panelists worried that Bextra, like many other arthritis drugs, might pose a risk.
He was on the panel and voted that Bextra should be kept on the market.
Pfizer Chief Medical Officer Joe Feczko had already defended Pfizer's arthritis medicines, Celebrex and Bextra.
Talley's second COX-2 entry, Bextra, was approved last year, beating out Merck's second version.
Second, there is an underlined and bolded warning not to use Bextra in patients undergoing heart bypass.
It also said that Celebrex and a related drug, Bextra, from Pfizer should continue to be sold.
But Vioxx caused an increased risk of congestive heart failure, and Bextra led to rare skin reactions.
But he says he feels the FDA's decision takes into account the totality of discussion on Bextra.
The panel had decided that although Bextra raised the risk of heart attacks, it had a place.
Pfizer says Bextra will have a serious warning that it can cause a potentially deadly skin reaction.
When Merck yanked Vioxx, investors at first thought Pfizer, which made rival drugs Celebrex and Bextra, would profit.
Instead, Bextra wound up off the market as well, and Celebrex struggled for years before regaining its footing.
Patients taking Bextra who develop the condition tend to get it in the first two weeks of treatment.
Since the recall of Vioxx, doubts have circled about both Bextra and Celebrex.
The Vioxx withdrawal has resulted in increased scrutiny for Celebrex and Bextra, which inhibit inflammation in the same way.
Additionally, some panelists say, the up or down vote on Bextra obscured more broad concerns about the drug's safety.
The vote for Bextra (17 for, 13 against, two abstaining) was very close to the 17-15 vote for Vioxx.
's earnings are still growing fast, but the risk due to pain drugs Celebrex and Bextra is only increasing.
Pfizer faces lawsuits over Bextra, a drug that, like Vioxx, contains COX-2 inhibitors.
And the vote for Bextra was close: Seventeen panelists voted for the drug, two abstained and 13 voted against it.
For Bextra, there is a 2.5-fold increase in risk, but so far this has only seen in heart bypass surgery.
In the 1990s he led the tiny team of chemists at Monsanto that invented the stomach-friendly painkillers Celebrex and Bextra.
Given the strength of those concerns, it seems unlikely that either Bextra or Vioxx is going to make a return.
But for the meeting to save Pfizer--or to settle the public's fears about Celebrex, Bextra, or Aleve--it needs to be credible.
She said that Bextra is still an important option for patients, but said that both side effects, though rare, are serious.
These drugs, along with a new Pharmacia drug, Bextra, are the only members of the Cox-2 class that are on the market.
Curt Furberg of Wake Forest University, had written scathing editorials about Bextra and Vioxx, yet was allowed to serve on the panel.
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