Real Betis have completed the signing of French born Poland international Damien Perquis from Sochaux.
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Shame their defense is a bit shaky, although they signed Spain international Juanito from Betis.
Guardiola's team still hold a 29-point lead over third-placed Valencia, who host Real Betis on Sunday.
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The following week Betis beats Real Madrid 1-0 and Sevilla loses 4-0 to Atletico Madrid.
Barcelona can win what would be its 22nd league title in the next round against Real Betis.
Real Sociedad drew 1-1 at home to Real Betis, a result which left both teams comfortably clear of the relegation zone.
In Thursday's other games, Real Betis made it through to the last eight with a 2-1 aggregate win over Las Palmas.
Following a 1-1 draw in the first leg, Ruben Castro's 85th minute strike sent Betis through to face Atletico Madrid in the last eight.
Sixth-placed Malaga drew 0-0 with Sevilla, while seventh-placed Real Betis won 1-0 at home to second-bottom Celta Vigo, with Ruben Castro scoring the second-half winner.
Earlier on Saturday in Spain Real Betis defender Miki Roque, a former Liverpool youth player, announced he needs surgery on a malignant tumour in his pelvis.
Granada suffered a 2-1 home defeat by Mallorca, Espanyol drew 0-0 with Valladolid and Real Sociedad shared a six-goal thriller with Real Betis as it ended 3-3.
There was just one game in Spain where Atletico Madrid went second in La Liga, and six points clear of city rivals Real, after winning 4-2 at Real Betis.
Real Sociedad claimed fourth place with a 4-1 win at home to Valladolid, while Valencia moved up to seventh with a 3-0 victory over fellow European hopefuls Real Betis.
The victory meant Real finished nine points ahead of archrivals Barcelona in second, who said farewell to departing coach Pep Guardiola with a 2-2 draw at Real Betis Saturday.
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Negredo netted his second from the spot before Manu del Moral completed the rout to set up a last-four clash with either Atletico Madrid or fierce rival Real Betis.
Madrid stayed second in La Liga with a 3-1 victory at home to Betis, as Germany midfielder Mesut Ozil scored twice and France forward Karim Benzema added the other goal.
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Fourth-placed Malaga spurned the chance to close the gap on Real after drawing 1-1 with Real Zaragoza, but Betis stayed a point behind in fifth after Diego Costa's 61st-minute winner for Atletico.
Barcelona had made the worst possible start as seventh-placed Betis took the lead in under two minutes through Colombia striker Dorlan Pabon, who scored his sixth goal since joining on loan in January.
Earlier, Junior Paulao scored as Real Betis moved up to third with a 1-0 win over Espanyol, who had midfielder Wakaso Mubarak sent off for a second yellow card in the second half.
Barcelona saw their lead at the top of the Spanish league cut to seven points at the weekend when they lost 2-1 to city rivals Espanyol and Real Madrid thrashed Real Betis 6-1.
However, Betis hit back with an even better effort as midfielder Ruben Perez -- on loan from Atletico Madrid -- fired in a piledriver from long range to give his side the lead at the interval.
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