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The East Coast route, running out of London King's Cross, serves locations including Peterborough, Leeds, York, Newcastle, Berwick upon Tweed, Edinburgh's Waverley station, Glasgow, Inverness and Aberdeen.
BBC: East Coast train
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The A96 polled 97 of the 359 votes cast in the survey of 13 routes, which also included journeys on the A75 Gretna-Stranraer and A1 Edinburgh-Berwick Upon Tweed.
BBC: NEWS | UK | Scotland | Highlands and Islands | A96 dubbed 'most unpopular route'
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National Express and CrossCountry services were suspended for a time between Berwick-Upon-Tweed and Edinburgh due to flooding near Dunbar.
BBC: Floods block east coast rail line
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Flooding is also continuing to affect East Coast rail routes including between Durham and York, and between Berwick-upon-Tweed and Newcastle.
BBC: St Asaph: Woman's body found inside flooded home
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Berwick-upon-Tweed is only the sixth place in the UK to be awarded Cittaslow status, an Italian term that translates as "slow city".
BBC: NEWS | UK | England | Tyne | Border town wins 'slow' accolade
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In Berwick-upon-Tweed, the ceremony started with a blast on a 12ft-high Celtic war horn, while churches in the Isle Of Man and Northern Ireland all took part.
BBC: Mass bell-ringing heralds Olympics opening