Norwich's miserable day on Merseyside was completed by a Ryan Bennett own-goal 15 minutes before the end.
Exodus Geohaghon and Ryan Bennett are likely to continue in central defence and Cooper has no further injury concerns.
Ryan Bennett, Scott Griffiths, Josh Simpson and Exodus Geohaghon are all on loan with a view to permanent moves.
The club have missed out on Grimsby's Ryan Bennett, Freddie Sears of West Ham and Stockport striker Oli Johnson.
Fellow defender Ryan Bennett and goalkeeper Joe Lewis should play having shaken off knocks, but Josh Simpson and Exodus Geohaghon are cup tied.
Zakuani has missed the past two matches with a thigh strain and could replace either Craig Morgan or Ryan Bennett in the back four.
Ryan Bennett, Scott Griffiths and Exodus Geohaghon are all set to miss out in defence, but Gabby Zakuani is fit to play alongside Craig Morgan.
With both Gabby Zakuani and Charlie Lee unavailable, Ryan Bennett filled in a right-back with Craig Morgan coming in alongside Exodus Geohaghon in the centre.
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Chris Whelpdale will also be handed a start with Reuben Reid likely to partner Izale Mcleod up front, while Ryan Bennett will return from suspension in place of Geohaghon.
The hosts were never in it after Craig Morgan saw red for a lunge at Campbell, and Ryan Bennett was then sent off for a professional foul on the same player.
"Everybody gets excited when Bob Friedland is pumping some stock, whether it makes sense or not, " says Ryan Bennett, principal at Resource Capital Funds, a Denver private equity group, who just returned from Mongolia.
Despite being a man light, Ospreys roused themselves and assaulted the Edinburgh line - Ryan Jones now to the fore and leading by example - which ended with hooker Huw Bennett barging over for a bonus point.
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