His cross provided the first chance of the game for Sami Khedira, whose header was saved by Diego Benaglio with the aid of the inside of his post.
Edgar Alvarez hooked over a cross for David Suazo, who could only plant his header wide, and then Alvarez himself drew a superb one-handed save from Swiss goalkeeper Diego Benaglio.
Leverkusen survived a late fightback to win 3-2 away to defending champions Wolfsburg, who had goalkeeper Diego Benaglio sent off for a professional foul on Eren Derdiyok after only 31 minutes.
Semih justified his second-half introduction when he rose highest to meet Nihat's superb inswinging cross from the left flank, and Benaglio could only palm the powerful header into the back of the net.
Perhaps the best chance of all for Fulham fell to Simon Davies, who was through on goal but saw his shot from 10 yards superbly deflected over the bar by the foot Benaglio.
Until Yakin's goals, Portugal winger Nani had missed the best chance in the 53rd minute when he shot wide when one-on-one with goalkeeper Pascal Zuberbuehler, who started in place of regular Swiss goalkeeper Diego Benaglio.
And Adam Johnson ensured England made the most of their numerical advantage as he scored a superbly taken second after 69 minutes, taking Gerrard's precise pass around Benaglio before turning the ball in from an angle.
England almost got the second goal their domination merited on the stroke of half-time when Rooney rounded Swiss keeper Diego Benaglio, only for Stephane Grichting to deny Defoe with a crucial clearance at the far post.
He broke the deadlock in the 59th minute, collecting an infield pass from Zoltan Gera before manoeuvring himself into a shooting position on the edge of the box and curling a superb shot past keeper Diego Benaglio.
Volkan made another superb save from Yakin, and Turkey held off the Swiss onslaught before Arda cut in from the right and fired a shot from just outside the penalty area which clipped the heels of Patrick Mueller and looped over the helpless Benaglio.
Liverpool's Glen Johnson demonstrated his defensive frailties against Bulgaria, but there is no question his natural attacking instincts add a different dimension to England, and he almost added a second with a low effort just after the break that Benaglio did well to turn to safety.
The in-form striker, who passed a fitness test before the game on an Achilles injury, collected a pass inside the area from fellow forward Zoltan Gera and stylishly set up a cool, side-foot finish past home keeper Diego Benaglio for his sixth Europa League goal of the season and 19th in total.
By this point Fulham could have been out of sight had Zamora's heavy first touch not allowed Benaglio to save at the striker's feet after he was free on goal or if Murphy's shot from a Paul Konchesky cross had been placed better so as to prevent a last-ditch goal-line clearance from Barzagli.
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