Trailing 29-28, England sent on Shane Geraghty at fly-half and Rob Webber at hooker, while fellow replacements James Haskell, Ben Youngs and Dan Ward-Smith also appeared on the hour.
As well as youngsters such as Ben Youngs, Chris Ashton, Ben Foden, Dan Cole and Courtney Lawes forcibly asserting their Test credentials, Johnson also took heart from the contributions of others to the second-string side.
Leicester were missing their England quartet Toby Flood, Ben Young, Dan Cole and Tom Croft, but Jordan Crane returned on the bench following a pre-season ankle injury, where there was also a place for loan scrum-half signing Jason Spice.
Wood's inclusion means that over a third of England's starting line-up will get their first experience of playing a Test in Cardiff, with Ben Foden, Chris Ashton, Shontayne Hape, Ben Youngs and Dan Cole also new to the Millennium Stadium Test experience.
BBC: Six Nations: Tindall leads England as Wood handed debut
CNN's Josh Levs, Saad Abedine, Ben Wedeman, and Dan Rivers and journalists Mohamed Fadel Fahmy and Ian Lee contributed to this report.
CNN's Ben Brumfield, Phil Gast, Dan Moriarty, Scott Thompson and Janet DiGiacomo contributed to this report.
Dan Blumberg of the Ben-Gurion University of the Negev, in Beer Sheva, Israel, has a more forceful approach.
CNN's Ben Brumfield, Stella Chan and Dan Gilgoff contributed to this report.
Who would have said this time last year that Dan Cole, Chris Ashton and Ben Youngs would be where they are today?
England will be without their most potent weapon at Pretoria, winger Dan Luger, but his replacement Ben Cohen is champing at the bit to impress after losing his place to Luger.
Promoted to the elite group for the first time are Leicester prop Dan Cole and scrum-half Ben Youngs, who have already established their Test credentials, Gloucester prop Paul Doran-Jones, and the uncapped Wasps centre Dominic Waldouck and Leeds flanker Hendrie Fourie.
Six position players are fighting over four spots in the infield and outfield, with major league vets Brennan Boesch and Ben Francisco likely having the best chance at landing outfield spots, and Jayson Nix and Dan Johnson the best possibilities for infield jobs.
The Steelers defence is now complete with Kevin Reiter and Dan Green sharing goaltending duties, and Bolibruck, Scott Basiuk, Randy Dagenais, Mark Thomas and Ben Morgan patrolling the blue line.
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