The typical clinical trial model may not be best suited for generating evidence that a drug is safe and effective against diseases where patient enrollment can be difficult and diseases progress slowly and unevenly over a long period of time, according to Steven Grossman, who worked on the original Orphan Drug Act in 1983 and is now a policy and regulatory consultant.

FORBES: Orphan Drugs: 'Rare' Opportunities To Make Money

Not to treat Mr George's acquittal as a miscarriage of justice "went behind the decision of the jury that acquitted him" and failed to take account of the fact that no safe conviction could ever be based on the evidence against him, the QC said.

BBC: Barry George loses compensation case

It is made by Bayer and its advantage is that it is already widely used against bronchitis, so it is known to be safe.

ECONOMIST: Tuberculosis

Mr Hilleman's greatest contribution to a healthy world may have been his work on the safe mass production of vaccines that can be stored ready for use against the pandemics that since antiquity have regularly swept across continents, such as the 1918 flu outbreak that killed more than 20m people.

ECONOMIST: Obituary

Because of these concerns and delays, it is safe to assume very few CO-OPs will be operating within the HHS mandated timeline to compete against other insurers in the health insurance exchanges.

FORBES: CO-OP Health Plans A Fiscal Cliff Victim

Defeat for Burnley against Liverpool on Sunday would all but confirm that West Ham are safe and ensure that Wigan will be in the top flight next season.

BBC: West Ham 3-2 Wigan