One of the Isle of Man's most famous landmarks will be lit up, following a series of repairs.
Special LED fittings were used so the tower can be lit up in different colours, the department said.
Birmingham Town Hall and the Dudley Canal Trust Tunnel and Cavern will also be lit up from 18:45 GMT.
To mark the end of the appeal, some landmarks will be lit up red, including Birmingham University's Clock Tower.
Cancerkin is also inviting people to sponsor one of the 2, 730 bottles which will be lit up in the pink and blue colours of the charity.
To mark the switchover the Crystal Palace transmitter, in south London, will be lit up on Wednesday night with 200, 000 watts of energy efficient lighting at a ceremony attended by Sir David Attenborough and DJ Chris Evans.
Nomadic Resorts unveiled The Looper, an amazing new prefab pod dwelling that can pop up anywhere, and one of the world's most famous museums, the Rijksmuseum in Amsterdam, will soon be lit up with 750, 000 new LED lights.
When the individuals heard dissonance, areas of their limbic systems known to be responsible for unpleasant emotion lit up and, moreover, the volunteers used negative adjectives to describe their feelings.
When he heard that I would be seeing you today his eyes lit up like I had never seen.
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When news broke that Disney had acquired Lucasfilm and would be making new Star Wars movies, a part of my brain lit up with the excitement I felt in 1977 and has been sparking every since.
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The beams of my headlights lit up hedges, hills, obelisks, but the girl, Diana, was nowhere to be seen.
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