In a market where Call of Duty sells a billion dollars worth of copies every year, it can be hard to make an impact doing something different.
So some of the new regulatory science policy work that FDA is doing could be hard hit, even if FDA is able to continue to keep pace with its day-to-day review function.
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But Norton believes that doing this hard work may be the key to a cure.
' In altering the structure of the intelligence community, it is essential to deliberate long and hard - and not to be stampeded into doing harm....Reform may now be necessary.
The researchers at Cern in Switzerland and Gran Sasso in Italy have tried really hard to find what they might be doing wrong - over three years and thousands of experiments - because they can hardly believe what they are seeing.
It is hard not to be excited by what the contemporary designers are doing.
Doing actual calculations with these trapped atoms will be hard, because the qubit stores must interact with each other during the process.
You cannot be afraid to take a long hard look at what you are doing and chuck it all out the window, if necessary.
At this price, Qwest's proposed merger would be so hard to pay for it would probably negate the value of doing it in the first place.
If you are running a small not for profit, this can be a tempting budget move, but I recomend you think real hard before doing it.
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If Johnston beats back the assault from Wal-Mart, it will be hard to know whether sales motivation or better throughput at the warehouses is doing the trick.
Most investors may be hard-pressed to earn 5% or better on their investments, and doing so may involve a lot of risk as well.
Even if News Corp does start charging and others follow suit, analysts say doing a U-turn on the free news model will be hard to pull off.
You're really worried about them and, you know, is they're going to be OK in what they are doing and it's just - it's hard.
So I don't -- it's hard to -- it would be hard to reconcile the notion that having health care reform didn't have confidence in doing this since they said the lack of health care reform is what caused -- purportedly caused such a sharp increase.
Main candidates are said to include both Motorola and Nokia, but Moto already seems to be doing just fine with the Q, and to be honest, it's hard to imagine Nokia snapping up a company that puts out phones running on Windows Mobile.
Truth be told, not only are these very often hard-working and widely-admired individuals who are doing things that are of great social value, but when they go to the store or a restaurant, they create jobs for those in the private sector, too.
"There would be days that would be so hard for me that Jamie Foxx would turn to me and say, 'How are you doing, Olivia, " she said.
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It can be hard to admit that one drug that you have been giving to a lot of patients may not be doing much of anything at all.
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What can reopen that portal is Pakistan's signing of the comprehensive nuclear test ban treaty championed by the U.S. But doing so without India, which is not hit as hard by the sanctions, will be politically damaging to Prime Minister Nawaz Sharif.
There are clearly hard issues of science and engineering at work here, but there seems little question that BP should be doing everything it can to fix the problem.
The United States would be hard pressed with the post-Clinton military to conduct larger-scale combat in Afghanistan, to say nothing of doing so simultaneously there and in, say Iraq.
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Which leads to the nub of the issue: it is hard to work out exactly how much damage resistant worms are doing, and thus how much effort should be put into trying to stop the spread of resistance not least because, as Dr Kaplan found out when he conducted his survey, the data are pretty sporadic.
See, ours is a fight for that basic bargain that built the largest middle class and the strongest economy the world has ever known -- the promise that hard work will pay off, that responsibilities will be rewarded, that everyone gets a fair shot, everybody is doing their fair share, everybody is playing by the same rules -- (applause) -- from Wall Street to Main Street to Washington, D.
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