Making up or those losses will be difficult even with great new drugs.
Egyptians are keenly aware that the next phase will be difficult, with the country's strained economy stressed further by weeks of unrest.
In some ways, it will be less difficult with the integration of gold into the financial system already through electronic payment systems.
Conditions on the moor were said to be extremely difficult with high winds creating drifts above head height and engulfing the entire road.
Re-establishing uninterrupted earnings growth momentum will be extremely difficult with an impetuous management style, and with a growing track record of surprising both customers and investors.
The Hammers' task was always going to be difficult, with Avram Grant's side without an away win in the league since the first game of last season.
This means that many retirees with pensions will have to search for individual health insurance coverage (which may be difficult for many with pre-existing conditions to secure), as well as pay the greater costs involved in non-group plans.
FORBES: A Nation on the Precipice: Our Failed Retirement System (October 12, 2007)
But if we keep kicking the can down the road, the problem just keeps getting worse, and then at some point it will be very difficult to deal with because the consequences will be so painful.
The conventional wisdom is that it will be difficult to compete with cheap generics.
FORBES: Can Pascal Soriot Turn Around AstraZeneca? It May Come Down To One Drug
The organisation also worries that limiting access to relevant findings would be difficult to square with its recently updated pandemic influenza preparedness framework.
It will be difficult, especially with the rear tires, and we know that other teams were stronger than us on the long runs on Friday.
It's been difficult in the past to completely freeze the assets of the Mafia and organized crime, and I think it would be even more difficult with a group as diffuse and international as this one.
With no election, I at first thought it might be difficult to come up with predictions, but as I began to write down some ideas, I found that there is indeed a lot going on worthy of discussion.
It is difficult to be precise with the figures as countries use different starting points and different criteria.
She believes the NHS will be left with the difficult, complicated work which will drive hospitals into financial failure.
"A Labrador that's over 100 pounds would be very difficult to deal with in a duck boat, " Ms. Gilchrist said.
In the physical world it can be difficult to sever ties with someone who is annoying you or is constantly bringing up the negative side of things.
FORBES: Grow Your Twitter Followers By Being Nice And Informative
Immunologists argue over the significance of this, but a number of them believe that it will be difficult to come up with a vaccine that covers all these strains.
"We're very happy to get 55 out of 57 points, but logically it will be difficult to repeat that with the Champions League and the Spanish Cup to think about as well, " Vilanova told reporters.
Murray, who beat Gael Monfils in Hamburg on Tuesday, admits that it will be difficult to find someone with the right credentials who is also willing to go back on the tour for 25 weeks a year.
He said that for the time being that would be very difficult, but that he would always be with us.
But, you ask, won't that be difficult when Glass is outfitted with prescription lenses one day?
We will all be discussing these difficult changes more with our teams and as a company.
ENGADGET: Zynga shutters Boston, UK and Japan studios, lays off 5% of full-time staff
When C. difficile bacteria overwhelm the gut, it can be fatal and difficult to treat with antibiotics.
These failures illustrate how difficult securitisation can be even with relatively straightforward assets.
Nonetheless, Ryan Heber will be coping mentally with a difficult situation, his father said, adding his son slept little Thursday night.
It will be difficult for a female candidate with little experience in security issues to gain the confidence of a majority.
It can be very difficult to get children with autism to focus.
应用推荐