And unless it is tackled, the prospects for future world economic growth might well be derailed.
It could well be derailed by the economy, by consumer spending, by crazy oil prices.
But all those potential bonanzas could be derailed if Mass Transit Railway stock goes off track.
And I do not think that the recovery we're starting to see will be derailed by this.
We cannot let the search for high-quality care be derailed by frivolous lawsuits and excessive damage awards.
These bills are a welcome first step in immigration reform, and should not be derailed by fallacious arguments.
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She knew better than to let my future be derailed by such feelings.
This time, Bloomberg has wisely chosen to circumvent a messy process that could be derailed by lobbyists and special interest.
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The welfare lobby, bureaucrats, and other recipients of taxpayer largesse are becoming increasingly agitated that their gravy train may be derailed.
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What is also being impressed on Mrs Clinton is the fact that the reform process is fragile and could yet be derailed.
Global growth is not going to be derailed by the quake.
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The Pars are currently top of the First Division and McIntyre is eager for the league campaign not to be derailed by the heavy defeat at Ibrox.
Deputy Prime Minister Nick Clegg said it was his party's position to extend civil partnerships to everybody, irrespective of their sexuality but the current bill could not be derailed.
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If Turkey does clip Mr Denktash's wings, it will be out of fear that the country's timetable for starting EU accession talks could be derailed if the Cyprus issue remains unresolved.
Yet the science of climate change has seemed to be derailed by climategate and the discovery of some errors in IPCC reports, even the gravest of which come far short of undermining its conclusions.
The three-city exhibition of Jackson memorabilia could be derailed, as relations between Jackson's mother, the men Jackson named as executors of his will and the promoter of his planned comeback concerts have been challenging.
Could the Dell LBO be derailed?
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And Premier League chairman Sir Dave Richards resigned from the board just weeks after six other board members stood down, while Karen Brady, one of those to quit her post, has stated the bid could be derailed by "infighting".
It will take many months, in some cases years, before Pena Nieto's reform agenda becomes law and produces its first results, plenty of time for big promises to be derailed by special interests, institutional inertia and the PRI's old guard.
It would be sad if it also derailed Rio's incipient revival.
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With such a large focus dedicated to maintenance, training and administration, the ability of IT managers to find the time and resources to invest in innovation, even process improvement initiatives will be hampered, if not completely derailed.
His comeback continued at Wimbledon as he reached the fourth round -- his best run at a grand slam -- but now his career has again been derailed by what appears to be a serious knee injury.
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Conrad expects approval by early 2006, but says that even if the merger is derailed, Cinergy and Duke will be just fine on their own.
More than 50 GPs in new clinical commissioning groups have warned that the NHS in England may be "in peril" if government changes are derailed.
The contract will be a relief for the European planemaker, as the order risked being derailed by a dispute between the European Union and China.
Rotating quarterbacks and a November injury to star running back Frank Gore derailed that possibility in a big way, and the Niners front office seems to be all right with that.
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