Similar problems have led drug companies including Novartis, Pfizer, and AstraZeneca to back off of or abandon psychiatric drug research.
Jason Heyward and Justin Upton hit back-to-back homers off of Robert Carson for the Braves.
Last time FDA had its budget clipped (by a much smaller amount) it used the shortfall as reason to back off some of its commitments under the Prescription Drug User Fee Act (PDUFA) to review applications on pre-determined timetables.
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The majority of problems these countries face can be traced back to strategy, to investments made off the back of excessive subsidies.
FORBES: Greece, Spain, Italy....How Do You Systematically Innovate a Country?
It was a system designed to dominate their struggling opponents but, despite coming into the game full of confidence off the back of four successive wins, they were unable to do so.
Despite the loss of Boyd Rankin, who had taken five wickets in the first innings, after Woakes had got rid of visiting skipper James Foster, Clarke took over the role as key strike bowler, knocking back the off stump of both Ryan ten Doeschate and Mark Pettini with fine deliveries.
BBC: Darren Maddy half-century helps Warwickshire beat Essex
Mr Hutton said he believed his son and one of his friends, who had both been at the front of the boat, were washed off the back of the boat.
Some Republican governors, however, did not back off their criticism of the stimulus package.
Five minutes later, the Basque went even closer when his left-foot strike from 20 yards came back off the foot of the post.
The Cardiff striker's long-range strike appeared to come back off the underside of the bar but referee Andy D'Urso judged the ball had crossed the line.
The queen of the turf made the long journey off the back of an undefeated career of 21 wins in 21 starts in her native Australia.
The Hammers almost equalised when Cole's shot from five yards out beat Boaz Myhill, but he saw his effort come back off the underside of the bar.
But the visitors came even closer moments later when Edwards saw his stinging shot from 25 yards come back off the underside of the crossbar and bounce to safety.
An effort from Taylor came back off the underside of the bar and substitute Johan Elmander sent a close-range shot over before Cahill nodded his sixth goal of the season.
Foster also denied Drogba from a deflected free-kick and then last season's Premier League top scorer saw his sensational header crash back off the corner of post and bar and to safety.
He turned and as he fell to the ground he managed to get a shot in from inside the six-yard box, but his effort came back off the underside of the bar.
James missed another three-pointer on the hour mark, just before Narraway took advantage of the new law variations to burst off the back of the scrum and cross unchallenged from 25 metres out.
It should have been 3-1 when Bale's trickery down the left prompted a terrible clearance from Rafael Schmitz that landed at Berbatov's feet, but his effort crashed back off the foot of the post.
Neil Carter picked up the first wicket, knocking back the off stump of debutant Grant Hodnett for 10, and there was a rare success for Jim Troughton when he found a way past Steve Adshead's attempted sweep after he had made 19.
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Full of danger, Owen missed an simple chance from six yards and tested Kirkland with a header, though Wigan could have gone 2-0 up after Henri Camara raced past Fabricio Coloccini and saw his shot come back off the inside of the post.
Phelps didn't allow another hit after Rasmus until Encarnacion hit his second long ball of the night leading off the sixth, a drive off the back wall of the Toronto bullpen.
Crane got his hat-trick just a couple of minutes into the second half with the number eight breaking off the back of a driving maul for Leicester's fifth try.
Given the puck at the point, Ehrhoff's shot sailed five feet wide of the net, caromed off the end boards and banked in off the back of Flyers goalie Steve Mason's skate.
But it was the briefest of honeymoons for Cook, lasting only until the last ball of the eighth over, when he played a half-hearted force off the back foot to a ball well wide of off-stump - and to the delight of the bowler Hilfenhaus, Michael Hussey dived expertly in the gully to take a fine one-handed catch.
Of course at this point the prospect would quickly back off by citing any number of obstacles yet to be overcome.
Part of my job involves reporting the Friday sittings of the Commons, when private members bills are debated - and Mr Nuttall has emerged as an enthusiastic player of the tactical games played by a group of Conservative back-benchers to kill off many of those bills (they see it as an exercise in legislative hygiene, stopping what they see as unnecessary and burdensome bills).
My rule is to write about decisions in the last couple of months and quite often I stick with the last couple of days, but the passing of Doctor Joyce Brothers has inspired me to get in the way-back machine and dust off Bank of Stockton v.
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If you do the basics well then you can build off the back of it.
Reagan and his followers never said the government should get off the back of big business.
Ma Lin's smashing forehands push his opponent ten feet off the back of the table.
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