The OBR itself "sees some risk" that some of the payments now tabled for 2013-14 will actually be made in 2012-13, as previously planned.

BBC: An 'optimal' Budget?

That could mean the results are close, but Novartis will have to wait until the trial is finished to file with the FDA. Another expected interim analysis from a second clinical trial will not be made public as was previously planned.

FORBES: Two Wins For Biotech

The company said it planned to open 130 to 140 new Gap International stores, up from the 120 to 130 previously planned, as well as 150 to 160 new Old Navy stores, up from the 120 to 130 previously planned.

BBC: Gap shares slide

Previously planned cuts to welfare and childcare are maintained in the new proposal as well as increased cuts to Medi-Cal, a government healthcare assistance programme.

BBC: California unveils plan to plug $15.7bn budget gap

Parreira, who returned for a second spell as South Africa coach in October 2009, having previously being in charge between 2007 and 2008, will now step down from his role with the team as planned for family reasons.

BBC: World Cup 2010: South Africa proud of team - Parreira