Northern Foods challenged Defra's position, saying authentic Melton Mowbray pies have been produced far from Leicestershire for over 100 years and complained of "the artificialnature" of the zone.
In July, the Center for Science in the Public Interest sued General Mills for allegedly putting artificial ingredients in Nature Valley products marketed as natural.
Michitaka Hirose, a professor specializing in virtual-reality technology at Tokyo University, traces Japan's thriving artificial entertainment industry to the art of bonsai, in which medieval nobility honed the reshaping of nature into an art form.