"The world is forwarded by having its attention fixed on the best things, " Matthew Arnold wrote.

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By itself, the absence of the 80-mg dose probably wouldn't have a great impact on Crestor's sales, Arnold wrote.

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Sir Arnold wrote that forecasting for the business was "extremely challenging".

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"Merck does not have a pipeline significant enough to offset these losses, " wrote Catherine Arnold, an analyst at Credit Suisse First Boston, in a note to investors.

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In another note to investors, Catherine Arnold of Credit Suisse First Boston wrote that most investors expected Merck to win both cases because both men were at risk for heart attack without Vioxx.

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But that strategy can run into problems: Catherine Arnold at Credit Suisse First Boston wrote in a note to investors this morning that there is a good chance Plavix will run into problems with the Federal Trade Commission.

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