Beginning this month the Hoechst-Ariad Genomics Center will test some 30, 000 genes for activity in forming bone cells.
Lowe, who works for a major pharmaceutical firm, was writing specifically about the Ariad case.
Among those who discovered the protein was Stuart Schreiber of Harvard, who helped found Ariad.
"Sarcoma is just the head of the train, " says Ariad founder and Chief Executive Harvey Berger.
The weird part:In cancer no drug should suppress the immune system, so Ariad's approach seemed inadvisable.
Ariad is not the first company to try to patent a broad swath of biology.
Since making that statement, Lowe had posted that he had shorted Ariad's stock ahead of the ruling.
Doctors said that numerous other companies, including Novartis, Ariad and Cephalon are working on ALK blocking drugs.
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However, Ariad's Berger says that his company's main goal will be to get licenses from already marketed drugs.
In the case, Ariad Pharmaceuticals, a tiny, money-losing biotech based in Cambridge, Mass.
Ariad Pharmaceuticals (ARIA) is interesting, with a massive 183% stock move and an average call option return of 35%.
This is a big deal for both Ariad and partner Merck, which has been trying to develop a presence in cancer.
Ariad and other biotechs once pursued only the broadest markets, but they have a newfound interest in curing the rarest of cancers.
Take the case of Ariad Pharmaceuticals and its sarcoma drug ridaforolimus, which succeeding at preventing tumor growth in a clinical trial announced today.
In the case, Ariad Pharmaceuticals (nasdaq: ARIA - news - people ), a tiny, money-losing biotech based in Cambridge, Mass.
He says basic scientists are free to inspect the pathway, but that Ariad expects a "reasonable royalty" for commercially available drugs that impact NF-kappa-B.
Then in May 2003 Boone became the first patient to try a new cancer drug from a faltering biotech boutique, Ariad Pharmaceuticals of Cambridge, Mass.
Making money from an Ariad trade was as much about calling a bottom in the stock as it was figuring out if ridaforolimus would prove effective.
The bigger shock is that Ariad, a publicly held shop founded 13 years ago on work by Harvard and MIT scientists, pursued this new drug at all.
Not surprisingly, Harvey Berger , Ariad's chief executive, disagreed.
Among the largest underlying components of XBI, in trading today Biogen Idec Incorporated ( BIIB) is up about 0.9%, and Ariad Pharmaceuticals Incorporated ( ARIA) is up by about 3.3%.
Unwanted side effects on the immune system could still emerge as a problem in Ariad's trials, but early data provide hope that mTOR drugs could attack other cancers as well.
Not surprisingly, HarveyBergerHarvey Berger, Ariad's chief executive, disagreed.
"The Ariad position is equivalent to discovering that gravity is the force that makes water run downhill and then demanding the owners of all the existing hydroelectric plants begin to pay patent royalties on their use of gravity, " says Armitage.
Among the largest underlying components of XBI, in trading today Spectrum Pharmaceuticals Inc ( NASD: SPPI) is up about 0.8%, ARIAD Pharmaceuticals, Inc. ( NASD: ARIA) is up about 0.5%, and Medivation Inc ( NASD: MDVN) is up by about 3.7%.
Among the largest underlying components of VBK, in trading today Oil States International, Inc. ( NYSE: OIS) is off about 0.7%, ARIAD Pharmaceuticals, Inc. ( NASD: ARIA) is up about 1.4%, and TW Telecom Inc ( NASD: TWTC) is lower by about 0.8%.
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