The Bush library offers one approach, mostly reflecting the views of his supporters, but Americans will debate the impact of those controversial eight years for a long time.

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However, this impulse can become destructive: if you spend a lot of time alphabetizing your spices or setting up eighty categories for your home library, consider simplifying your approach.

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Synta, on the other hand, uses the same basic approach that drug companies have used for centuries: taking a library of thousands of chemical compounds, and testing those compounds one by one in the lab until something seems to work.

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