The expansion of the original United States from the Appalachians to the Pacific and the Rio Grande had indeed required dealings with outsiders.

ECONOMIST: THE WAR OF 1898

If I had to live east of the Mississippi, I might choose Knoxville, which lies on the western slope of the Appalachians and resembles the Sierra Nevada foothills.

FORBES: Anecdotes On The Economy

Alex Sosnowski, a meteorologist for Accuweather, said the storm will push off into the Great Lakes and central Appalachians, and freezing rain could make it as far east and south as North Carolina.

NPR: Winter Storm Blankets Great Plains With Snow