Apo A-1 is thought to be the key HDL component that removes cholesterol from cells.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Almost a decade ago a study demonstrating regression of atherosclerosis with apo A-1 Milano caused tremendous excitement, but the recombinant product has not yet undergone further research or commercial development.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
An even more unusual approach is being explored by Alan Fogelman and his team, who have genetically engineered a tomato to produce a small peptide, 6F, that mimics the action of apo A-1.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Among both Finns and French, people born with an apo E-2 gene have a four-fold greater likelihood of reaching 100 than those born with an apo E-4, the studies find.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The ball went left, but Northampton back-row Apo Satala put in a magnificent cover tackle to deny Brian Mujati a try in the corner.
Zannis, first discovered 17 years ago that there were three versions of apo E, they found that most people afflicted with a rare type of artery-clogging atherosclerosis had two copies of apo E-2.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The only disease linked to apo E was a rare type of artery-clogging atherosclerosis.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The surprise was that although men with a copy of the apo E-4 gene made up less than 16% of the group, they accounted for 26% of the heart-disease deaths.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Possessing an E-2 or E-3 version of apo certainly isn't a guarantee of avoiding Alzheimer's.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
"The hope is that we can make a drug that does what apo E-2 does, " he says.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Until recently there were two ways to visit Apo: you could shell out for a live-aboard dive safari operating out of the town of Puerto Galera in eastern Mindoro, or out of Coron town in Palawan province south of Mindoro.
But if a patient has two copies of apo E-4, the odds that the dementia is due to Alzheimer's jumps to 94% from 66%, the Duke scientists say.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
But excited researchers say that apo E is rapidly emerging as the first-found of a set of mysterious genes that roughly determine how long a person will live, provided he or she escapes an "unnatural" death from bacteria and viruses, war, accidents, unhealthy diet, smoking or other environmental happenstance.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
He is working with a major drug maker to find out why apo E-2 seems to be protective.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
As for cement, Gokongwei expects a glut in three years, but says 34-year-old Apo Cement will remain competitive.
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