Of course you do not need to be a diver to enjoy the charms of Apo Reef.
Also listed are French under-17 internationals Irele Apo and Serge Akakpo, both of AJ Auxerre.
The only disease linked to apo E was a rare type of artery-clogging atherosclerosis.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Fewer French people have an apo E-4 gene, but the pattern is the same.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Possessing an E-2 or E-3 version of apo certainly isn't a guarantee of avoiding Alzheimer's.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Apo A-1 is thought to be the key HDL component that removes cholesterol from cells.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Specifically, the Duke scientists checked the apo E of people with Alzheimer's disease and their close relatives.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
"The hope is that we can make a drug that does what apo E-2 does, " he says.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Apo-E is thought to stop the damage being done to the cholesterol, but with varying degrees of effectiveness.
He is working with a major drug maker to find out why apo E-2 seems to be protective.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
As for cement, Gokongwei expects a glut in three years, but says 34-year-old Apo Cement will remain competitive.
But Apo Satala crossed just after the break and Olly Barkley's penalty put Gloucester ahead for the first time.
The evidence so far indicates that apo E is one of an unknown number of "housekeeping genes, " says Allen D.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
In the case of apo E, Dr. Roses hypothesizes, the different versions vary in their housekeeping finesse, just as human housekeepers do.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
There are three different but normal versions of the apo E gene and its protein, known respectively as E-2, E-3 and E-4.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Death from coronary heart disease also seems to correlate with apo E.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
In Finland, about 50% of middle-aged Finns possess an apo E-4 gene.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Over the same period the productivity of the workforce increased by over 9% a year, according to the Asian Productivity Organisation (APO).
The ball went left, but Northampton back-row Apo Satala put in a magnificent cover tackle to deny Brian Mujati a try in the corner.
So, should I open the envelope from Rockefeller, where my apo E status was determined by Dr. Breslow's laboratory as part of a research project?
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Dr. Roses, however, has a more compelling interest in apo E.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Since 1984, researchers in Helsinki, working with University of Michigan geneticists, have been monitoring the fates of 666 elderly men whose apo E type was known.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
But if a patient has two copies of apo E-4, the odds that the dementia is due to Alzheimer's jumps to 94% from 66%, the Duke scientists say.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The novel antisense oligonucleotide works by inhibiting the synthesis of apo-B and is under development in the United States and Europe for the treatment of familial hypercholesterolemia.
FORBES: CHMP Recommends Against Approval For Mipomersen In Europe
The surprise was that although men with a copy of the apo E-4 gene made up less than 16% of the group, they accounted for 26% of the heart-disease deaths.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Among both Finns and French, people born with an apo E-2 gene have a four-fold greater likelihood of reaching 100 than those born with an apo E-4, the studies find.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Also within the atoll-like reef system are picturesque islands that are mid-ocean pit stops for a variety of migrating seabirds, giving twitchers almost as much reason as divers to be excited about Apo Reef.
Almost a decade ago a study demonstrating regression of atherosclerosis with apo A-1 Milano caused tremendous excitement, but the recombinant product has not yet undergone further research or commercial development.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Zannis, first discovered 17 years ago that there were three versions of apo E, they found that most people afflicted with a rare type of artery-clogging atherosclerosis had two copies of apo E-2.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
An even more unusual approach is being explored by Alan Fogelman and his team, who have genetically engineered a tomato to produce a small peptide, 6F, that mimics the action of apo A-1.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
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