Revimid, in any case, was designed to be a more potent and safer version of Celgene's existing drug, Thalomid, which was linked to birth defects when used decades ago as an anti-nausea treatment during pregnancy.

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Crystal's nervousness is understandable - though doctors say that if HIV-positive women take anti-retroviral drugs during their pregnancy and avoid breast-feeding, the chance of their baby carrying the virus is tiny.

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Prosecutor Sarah Munro QC told the court that during her pregnancy Mrs Norris was prescribed anti-depression medication.

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Writing in JAMA, the researchers led by Dr Lee Cohen, said the prevalence of depression in reproductive age women, their level of anti-depressant use and the frequency of unplanned pregnancy, it was important to be able to tell patients about comparative risk of relapse linked to stopping or continuing with their medication.

BBC: NEWS | Health | Pregnancy 'no depression guard'

All the participants had a history of major depression prior to pregnancy, were less than 16 weeks pregnant, and were either current or recent users of anti-depressants.

BBC: NEWS | Health | Pregnancy 'no depression guard'