Tom James and Andy Powell scored first-half tries and Munster's Denis Leamy and Kieran Lewis hit back.
Wing Tom James took the move on and then Andy Powell was dragged down yards short of the Bath line.
Blues pair Leigh Halfpenny, 19, and Andy Powell, 27, will win first caps.
That left Jamie Roberts as the sole Blue Lion behind the scrum with Martyn Williams and Andy Powell up front.
Lee Byrne returns to replace Hook at full-back while Ryan Jones comes in at number eight for injured Andy Powell.
There was an early Lions injury scare when Andy Powell needed treatment after pulling a maul down on top of himself.
Blair re-established the Blues' 10-point lead after Andy Powell made inroads down the left and Gloucester earned referee Alain Roland's wrath.
However, a Medard kick ahead caught Wales out, Andy Powell chasing back only for the visitors to commit an accidental offside.
Phillips and number eight Andy Powell stayed on to talk to customers.
But he switched to the back-row soon after half-time, replacing Andy Powell.
The Ospreys star, 27, and Andy Powell, Rhys Thomas and Jonathan Thomas had already apologised to the Welsh Rugby Union over their behaviour.
Lee Byrne, Jamie Roberts, Andy Powell, Matthew Rees, Adam Jones, Scot Mike Blair and England flanker Joe Worsley will also play their first Lions match.
Back-row replacement Andy Powell proved his value as an impact player with some powerful running, but Toulouse continued to threaten as the minutes ticked away.
But Williams, Jones and Andy Powell - now dropped for disciplinary reasons - were outshone by Scotland's back-row and must up their game against France.
BBC: Wales boss Gatland warns Martyn Williams and Ryan Jones
Andy Powell at number eight stood alone on performance for Wales.
But for all the confidence of that record and some typically robust running from number eight Andy Powell, the Blues found themselves conceding the opening try.
An early drive from the base of the scrum by Blues number eight Andy Powell set the scene for the night, with the Connacht defence already back-pedalling.
That match also saw his Cardiff Blues team-mate Andy Powell make his Wales debut, with a man-of-the-match performance that has helped the number eight's own Lions selection.
Ex-skipper Ryan Jones remains at number eight following his showing at Murrayfield, where he started in the wake of the shoulder injury that forced Andy Powell off against England.
Saracens increased their lead four minutes after the break, with Farrell this time kicking a 40-yard penalty and five minutes later he struck again after Andy Powell was caught offside.
Andy Powell, fresh from some barn-storming displays for Wales, was on hand to take the scoring pass, only for his scrum-half to spin the ball behind his supporting number eight.
But he came on for the injured Andy Powell in that defeat before starting in Wales' wins in Scotland and Italy, hitting some of his best form in a red jersey.
Williams and Jones join Gethin Jenkins (calf), Peel (groin), Mike Phillips (ankle), Alun Wyn Jones (elbow), Andy Powell (discipline) and Matthew Rees (groin) in seeing their Six Nations campaigns disrupted or ended.
Number eight Andy Powell's contribution was even more telling for the visitors as he claimed the man-of-the-match award while full-back Jason Tovey's tactical kicking at counter-attacking helped him shine for the Dragons.
Should the Wales skipper be ruled out youngster Sam Warburton is also an option to step in against Ireland, while there is speculation that Andy Powell could receive a recall after his drink-driving golf-buggy disgrace.
England's Joe Worsley could make the plane and Wales' Andy Powell, Ireland's Alan Quinlan, the Scottish pair of Alasdair Strokosch and Allister Hogg and England's Tom Rees can all have a case made for them.
Ireland's Jamie Heaslip (two votes) and Wales' Andy Powell appear to be front-runners for the number eight jersey, though Wood believes Irishman Denis Leamy, who saw limited Six Nations action, "could end up at number eight".
After Evans made a hash of a long penalty for the Scarlets, Blair extended the home side's lead with two further kicks as burly Andy Powell joined the fray to give the Blues' attacks some added impetus.
Wales number eight Andy Powell signing for Wasps was a strange one - nobody expected that - but Shaun Edwards knows him really well from the Wales set-up and Powell will certainly know what he's signed up to.
For instance, O'Connell and Simon Shaw in the second row is a possible one, but I'm not sure we'll see Saturday's back row of Joe Worsley, Martyn Williams and Andy Powell in the first Test - it doesn't look right to me.
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