Spanish 26th seed Marcel Granollers will play Tsonga or Mello if he defeats Portugal's Frederico Gil, while Argentina's world No. 29 Juan Ignacio Chela could face Ferrer if he gets past Spain's Pablo Andujar.
Manhattan cut the lead to six on a steal and layup by Emmy Andujar with 2:30 left, forced a shot-clock violation and made it a four-point game on a pair of free throws by Rhamel Brown.