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Andriy Pyatov saved Ibrahim Afellay's shot as the visitors eased through 1-0.
BBC: Shakhtar 0-1 Barcelona (agg 1-6)
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The English team took the lead in the sixth minute when Spain striker Fernando Torres charged down an attempted clearance by goalkeeper Andriy Pyatov following a poor backpass by Yaroslav Rakitskiy.
CNN: Barca's unbeaten run ended by Celtic
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They could have gone in front inside 15 seconds when Brede Hangeland's header was superbly tipped over by Andriy Pyatov, but the Cottagers only had to wait two more minutes to nudge ahead.
BBC: Fulham 2-1 Shakhtar Donetsk
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Lionel Messi's through ball was intended for David Villa but when the ball broke off a defender into the path of Iniesta, he took full advantage, haring into the box and coolly firing past Andriy Pyatov.
BBC: Barcelona 5-1 Shakhtar Donetsk