The Carretera Austral could be one of the most spectacular and challenging cycle tours in the world.
"This has been a difficult and challenging few days, " said U.S. military spokesman Maj.
But, of course, this region has always been pristine frontier, rugged and challenging.
Mr Salmond accepted that the provision of cancer drugs was a "hugely difficult and challenging issue".
But Hilda turned from the checkout with a face of pure resentment, staring and challenging.
Moving up to a new level is rewarding and challenging at the same time.
Having a single-person business is exciting and challenging, no matter what the economy does.
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We have some of the most beautiful and challenging road biking on all the Earth.
Photos and stories flooded in of people celebrating multiple cultural traditions and challenging perceived stereotypes.
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But emotion is complex and challenging to capture through sounds and dialogue and gameplay.
The landing approach was, by far, the most difficult and challenging part of the flight.
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Teaching is a rewarding and challenging profession where you can make a lasting impact.
Hollywood knew it was telling stories so exciting and challenging that audiences would suspend disbelief.
The infestation will only worsen and become more costly and challenging to treat.
When you're tackling a new and challenging topic, starting from a solid foundation is crucial to success.
However, some children have extremely difficult and challenging behaviours that are outside the norm for their age.
However, TAN has rebounded in recent sessions, overtaking its 10-week trendline, and challenging its 20-week moving average.
National STEM design competitions will develop game options to engage kids in scientific inquiry and challenging designs.
To what extent are such measures quantifiable and challenging vs. a walk in the park (so to speak)?
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These are the makings of a very interesting and challenging year to come.
It features six people talking about their past and present lives, exploring their personal histories and challenging conventional language.
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"Mental arithmetic is a more complex and challenging task, which more than 20% of people struggle with, " the study said.
The incident involved up to 20 fans from each club shouting threats, swearing and challenging each other to a fight.
Teresa Budrey, of the Sussex RCN, said staff were "desperately trying to deliver good care in difficult and challenging circumstances".
The conversation, thanks in part to an active and engaged audience, and wonderfully diverse questions, was invigorating, informative and challenging.
And labor, with accompanying pain, fast heartbeat and hormonal changes, "that's the most dangerous and challenging time, " Dr. Franklin says.
Iger says social, global and mobile, plus cloud storage, makes for an exciting, interesting and challenging time for the media business.
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"I am absolutely delighted to have been given this opportunity, which is exciting and challenging in equal measure, " said Ms Yates.
Det Insp Dave Williams said West Mercia Police's investigation had been "complex and challenging" and added it was "not over yet".
We all know that a startup company is a roller coaster ride, with exhilarating, thrilling highs, and challenging, even scary lows.
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