Powell intercepted to finally get Saracens on the board nine minutes after the interval and they added a second score soon after when Yates powered over against his former club, with Glen Jackson converting both.
After Eastmond's try, England prop James Graham crashed over for his second try of the match and winger Francis Meli added a late score to give Saints a flattering margin of victory.
De Villiers and Boucher added a further 10 to that score, moving the overall lead to 62, when De Villiers, on 11, found himself on strike to Graeme Swann.
BBC: England on course for heavy defeat in Johannesburg Test
Burrow took advantage of the weather conditions by jinking past two tackles and sliding over the line to open the scoring, and McGuire added to the lead when he picked up a loose ball and raced away to score.
However, Antrim were not to be denied as Kevin Niblock calmed the nerves with a score from play and Cunningham added another free.
McCullagh then added another score after a superb flowing move and it then got even better for the Red Hand County in the sixth minute.
England wing Ugo Monye added a third after the break when he snatched a stray pass deep in his own half and raced 70 metres to score under the posts.
Bortolussi increased the lead seven minutes later and Italy could have added a second try but hooker Carlo Festuccia's score was ruled out when video evidence indicated he had taken the ball into touch.
He collected Paul Deacon's kick to score, despite suspicions of a knock-on and added a second, racing clear after receiving a pass from James Evans.
He laid the platform for Elliott to score a try three minutes into the second half, and added the conversion to give Newcastle a 14-10 lead.
Masters officials discovered late Friday evening that Woods had taken a bad drop in the second round and should have added two shots to his score.
Byrne has been a revelation in this Six Nations and his two tries against Italy added to his score in the shock opening win against England at Twickenham.
Lock James Horwill charged onto George Smith's pass for the opening try, Giteau added a penalty before converting the first score by Mitchell, who picked up and beat four defenders before stretching over.
Scrum-half Tomas O'Leary added the conversion and did likewise after replacement Howlett speared through a gap and outpaced Aled Brew to score behind the posts.
De Villiers added 48 to his score of 11 - and the two decisions combined help South Africa build a huge lead over England in Johannesburg.
Cameron Smith added a sixth before captain Darren Lockyer scored a national record 34th try, and Tonga's second score rounded off the win.
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