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Top seed Roger Federer begins against Colombia's Alejandro Falla, while Nadal plays Kei Nishikori of Japan.
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The 23-year-old doubles specialist, ranked 113th in singles, will next play Colombia's Alejandro Falla.
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He begins his campaign against Colombia's Alejandro Falla, the man who took him to five sets at Wimbledon in 2010.
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The Frenchman edged out Colombia's Alejandro Falla 7-6 7-6 in intense heat.
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Elsewhere, Juan Martin Del Potro eased past Colombia's Alejandro Falla 6-2 6-2 to set up a third round clash with France's Michael Llodra.
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Colombian Alejandro Falla handed victory to Bulgarian 26th seed Grigor Dimotrov while Germany's Florian Mayer , seeded 28, quit during his clash with Denis Istomin of Uzbekistan.
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In the remaining second-round matches to be completed, Julien Benneteau won 6-0 in the fifth set to edge past Colombia's Alejandro Falla, while Florent Serra needed four tight sets to eliminate Romania's Victor Hanescu.
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Eighth seed Fish was less happy to play in the scorching afternoon heat, complaining about the timeouts that Colombian opponent Alejandro Falla took for treating cramps before sealing a 7-6 (7-4) 6-3 7-6 (8-6) victory.
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