Plastic surgery has been affected profoundly by the economics of publicly funded health care in the West.
It is profoundly affected by social factors such as poverty, early life experiences and trauma.
Braque, as a thinking person and loyal Frenchman, was profoundly affected by the war years.
She is said to have been profoundly affected by her parents' divorce while she was still in school.
Like all creatures, humans exist in time and are profoundly affected by it.
But it would be difficult to identify a sector that will not be profoundly affected by the advent of the boomer-geezer.
He said it was a fitting tribute to a man who profoundly affected and touched the hearts of everyone he met.
After the game a teary-eyed Jim Joyce apologized for missing the call and it was clear the mistake had profoundly affected him.
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Jay Wilson, the commission's vice chairman, visited Japan and said he was profoundly affected as he walked through villages ravaged by the tsunami.
In a music career spanning more than 40 years, Nick Lowe has profoundly affected the music industry as a singer, songwriter, and producer.
Music, film, TV, videogames, newspapers and magazines have all been profoundly affected by the explosion of new devices that enable the consumption of digital media.
One such major challenge that we all face in Africa is HIV and AIDS. Even though the epidemic has profoundly affected all our societies, it remains cloaked in silence.
While there is no doubt Littleton was profoundly affected by Martha Moxley's murder and its subsequent investigation, to what end his problems can be attributed to this event is uncertain.
The self-proclaimed nerd, like many Star Wars fans, has been profoundly affected by the franchise as he explains in this short conversation with Richard Bacon on BBC Radio 5 Live.
He was much more profoundly affected by the death in March 2011 of George Desdunes, an older friend from sleep away camp and the neighborhood who died in an alcohol-related hazing incident at Cornell.
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And of course, especially with the non-profits such as Komen, there are passionate people involved who have been profoundly affected by their experience with the disease, and their emotions play deeply into the decisions those organizations make.
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