But the conflict is particularly acute when the subjects of the research are vulnerable for instance, if they are mentally ill and confused, if they are poor or homeless and in need of money, or if they are seriously ill and desperate for any sort of help.

ECONOMIST: Don��t let it happen again

Describes Emil Freireich's research into drugs to treat acute lymphoblastic leukemia (ALL) in the nineteen-fifties and sixties.

NEWYORKER: The Treatment

However, it recommended more resources for research on the chemistry, pharmacology, acute harm, and the social harms of legal highs.

BBC: Legal highs need more controls, say drug council