These medicines, called acyl-CoA cholesterol acyl-transferase (ACAT) inhibitors, aim to prevent plaque from sticking to the walls of the arteries.

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Second, the testimony that every single client on the list of customers to whom he sent an overnight package requested the enclosed ACAT forms strains credulity (particularly since most of these customers did not actually transfer their accounts).

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Pfizer had aimed to develop its own ACAT inhibitor, but the drug failed to show a benefit. (See: Pfizer's Cardiovascular Failure) But some of the problems with that drug may have come from the fact that it interacted with Lipitor, preventing cholesterol from being lowered enough.

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