Other than the enforced absenceof Vickery, the other two personnel changes from the win over the United States are in the back row, with Worsley and former captain Dallaglio the players to make way.
The government asked Professor Carol Black and the former head of the British Chambers of Commerce David Frost to consider radical changes to deal with the human and financial cost of sickness absence in the workplace.
They argued that it was the absenceof unions at charter schools that allowed administrators to make quick changes to staffing and scheduling in the pursuit of innovation.
The absenceof Borthwick means England's starting side now shows six changes in personnel - two enforced by injury - from the one that lined up at Murrayfield.