There is very high certainty from well-designed trials that colon cancer screening, combined with effective follow-up and treatment of abnormalfindings, reduces risk of colon cancer death by at least 35 percent and risk of getting colon cancer by 20 percent.
The donor advocate is supposed to take into account only the donor's concerns -- for example, in Paul's case, the abnormal EKG findings -- and not the concerns of the recipient, since sometimes there can be a conflict of interest between the two.