"These findings define a new drug target with wide potential for therapeutic intervention in conditions such as hormonal-dependent cancer, abnormal puberty and control of fertility, " said Dr Samuel Aparicio of Paradigm Therapeutics.
To fail in these conditions is in part to be a victim of abnormal circumstances, which almost by definition few management teams are experienced at facing.
This includes people with conditions such as an artificial heart valve, past history of endocarditis or a heart transplant with abnormal heart valve function.