He wasted one with a double fault and Roddick, urged on by a home crowd, saved two more.
The second seed took the lead for the first time in the third game of the opening set when he reached a well-placed volley by Roddick and fired a down the line winner back past his unbelieving opponent.
The third-seeded Moroccan, who was beaten by Andy Roddick in a dramatic quarter-final in Melbourne, lost his first-round match 7-5 6-3.
Seventh seed Roddick weathered a storm against Chile's Fernando Gonzalez before winning 6-3 3-6 4-6 7-5 6-2 in a big-hitting contest under the lights.
His son Tal was fighting the north Wales PCC seat for Labour but he came second to independent candidate Winston Roddick, a barrister and former senior legal adviser to the assembly.
Djokovic's fourth round clash against Marcos Baghdatis on Sunday night ran into the early hours of Monday, but the third seed's request to play Roddick in a night match fell on deaf ears.
Andy Roddick had a busy Thursday night.
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She went to New York this year determined to savor the occasion, playing in the singles, doubles and mixed doubles competitions while also watching as a fan as Andy Roddick ended his career during the grand slam event.
Roddick had a break-point opportunity in the next game but failed to take it and he was made to pay dearly for that in the fifth when Federer broke him again then comfortably held serve for a 5-1 lead.
Labour MP David Hanson has a ten minute rule bill requiring candidates in elections who stand as independents to declare if they are members of political parties - his Local Police and Crime Commissioner is Winston Roddick, a Liberal Democrat member who ran as an independent (although there was no particular secret about his party involvement).
That much was clear from the very first point against Djokovic - a visibly nervous Berdych opening proceedings with a double-fault - but against Roddick he looked sharp and confident from the outset, clipping a beautiful forehand winner up the line in game one.
BBC: Tomas Berdych finds form to beat Andy Roddick in London
Second seed Roddick found things a bit tougher than Federer, but still won in three sets, 6-3 7-6 7-6.
Sixth seed Andy Roddick then completed a good night for the Americans by beating Sweden's Thomas Enqvist 6-4 6-4.
"You have to understand -- people see tennis a lot, " Andy Roddick said.
Roddick has had a poor time over the last year but had improved recently under the guidance of new coach Jimmy Connors.
For example, Brad Gilbert (Agassi, Roddick) has a TV contract in the USA and Bob Brett (Becker, Ivanesevic) runs his own academy in Italy.
Roddick led by a set and had four set points in the second set tiebreaker before the Swiss maestro clawed his way back into the match in the space of a few moments.
American Andy Roddick advanced with a 6-3 6-4 6-1 success over Dutch world No. 53 Robin Haase, and the 15th seed will next play fellow former world No. 1 Lleyton Hewitt of Australia.
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Other sports starts quickly got in on the act, peppering Dufner's Twitter timeline with their own version of the online phenomenon -- former tennis player Andy Roddick even tweeted a picture of his dog "Dufnering".
CNN: Points joins in 'Dufnering' craze after Houston Open win
The only note of caution so far came at last year's US Open where he was demolished by Sampras, who highlighted a lack of variety in Roddick's game from the back of the court that could be particularly telling against the best baseliners.
Murray produced a tenacious performance on Saturday to upset third seed Andy Roddick on Saturday but just two days later, he was a completely different player.
Cilic will face Andy Roddick after coming through a marathon fourth-round match after four hours and 38 minutes.
Roddick however was given a tough passage to the later stages with a possible second round match against either German Tommy Haas or Croatian Mario Ancic .
His baiting of the New York crowd at the 2008 US Open after a spat with local hero Andy Roddick was ill advised to say the least.
In the meantime, Roddick, who scored a superb victory in the Miami Masters 100 tournament recently, is hoping that Isner and Querrey can step up to the plate to give him some support in the upper echelons of the world game.
Those two matches proved two factors that are key to Roddick's game - a huge serve and an even bigger heart.
L'Oreal said it planned to operate the British company as a stand-alone business with Anita Roddick remaining in her current role as consultant.
The American tennis world was tossed into a tizzy on August 9th when Andy Roddick fell out of the top ten in the ATP rankings.
FORBES: Are Reports of the Death of American Tennis Premature?
Having already won the Australian Open and Wimbledon this year, and with a 10-1 career record against Roddick, it was no surprise when Federer started superbly.
Nalbandian, a late replacement for the injured Andy Roddick, looked set to match Federer's efforts after storming through the first set against Davydenko in 25 minutes.
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