"The biggest mistake of ablation was that there wasn't a big randomized study when the technology came out, " he says.
It is a randomized controlled study, meaning that similar patients were assigned at random to either get either Centrum or placebo.
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For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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The latest study, a randomized trial of 80 women and men published in Plos One by Harvard researchers, shows that even when clinicians told women with irritable bowel syndrome they are getting fake pills, the fake pills still worked.
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In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
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There has been only one study using a large randomized sample, objective measures of well-being, and reports of grown children rather than their parents.
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Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
In a 28-week study of Alzheimer's patients, 250 were in a randomized trial to memantine or placebo.
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All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
To really know whether antidepressants have long-term health risks, one would have to do a very, very large study in which 50 percent of the subjects were randomized to receive an antidepressant and the other 50 percent were randomized to take a placebo pill.
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