The treatment was common until a randomized controlled trial proved it was actually harming women.
It is a randomized controlled study, meaning that similar patients were assigned at random to either get either Centrum or placebo.
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More substantial and convincing support for such a recommendation to eat cherries as a way to reduce gout flares would ideally emerge from a randomized controlled clinical trial.
The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
But I think that before embarking on a large randomized controlled trial he first needs to demonstrate that such a trial would even be feasible.
But surgery sometimes goes mainstream without ever being evaluated in a randomized, controlled trial.
He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
But a related Abbott drug, TriCor, failed to prove its benefits in a large randomized controlled clinical trial.
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The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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All of the studies ran for at least a year, and all were randomized controlled trials, the most rigorous type of study.
It is because the government-funded trial was a placebo-controlled, double-blind, randomized controlled trial.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
Several studies that followed large groups of people as they aged have suggested that a diet rich in fish is linked to a reduced risk of dementia and mental decline, but most randomized controlled trials comparing DHA supplements with placebo have found no benefit.
Safety data for KYNAMRO are based on pooled results from four Phase 3, randomized, double-blind, placebo-controlled trials with a total of 390 patients of which 261 patients received weekly subcutaneous injections of 200 mg of KYNAMRO and 129 patients received placebo for a median treatment duration of 25 weeks.
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We have a set of plausible and interesting hypotheses to work with, and now we need some randomized controlled trials to give us data we can really use.
In healthcare, our gold standard for good evidence is the randomized controlled trial, in which, for example, half the patients receive a new drug and half receive a placebo.
These are the kinds of big, randomized, controlled studies that the U.S. Food and Drug Administration requires before a new drug is approved.
The authors noted that there has never been a controlled clinical trial of parachutes, and facetiously suggested that one be conducted in which subjects were randomized to jump from a plane either with or without a device.
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