The treatment was common until a randomized controlled trial proved it was actually harming women.
But surgery sometimes goes mainstream without ever being evaluated in a randomized, controlled trial.
With a randomized minimum wage, it would apply randomly to different states or counties.
In a 28-week study of Alzheimer's patients, 250 were in a randomized trial to memantine or placebo.
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He currently is recruiting post-stroke patients for a randomized, controlled trial comparing error-type treatment to intensive treadmill training.
Patients are now being recruited into a randomized, multicenter trial--the kind that the FDA demands before a drug can be approved.
It is a randomized controlled study, meaning that similar patients were assigned at random to either get either Centrum or placebo.
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Then when a randomized trial showed that hormonal replacement therapy actually raised the early risk of heart attack, women were understandably upset.
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The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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In 1988, the American doctor Randolph Byrd recruited some born-again Christians to pray outside a San Francisco coronary care unit for a randomized group among 400 patients.
More substantial and convincing support for such a recommendation to eat cherries as a way to reduce gout flares would ideally emerge from a randomized controlled clinical trial.
In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
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The Cambridge group will begin a randomized controlled trial next month with 104 children involved, similar to the peanut study done already, but with controls, said researcher Dr. Andrew Clark of Cambridge University Hospitals.
The latest study, a randomized trial of 80 women and men published in Plos One by Harvard researchers, shows that even when clinicians told women with irritable bowel syndrome they are getting fake pills, the fake pills still worked.
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It is indifferently acted and in too much of a rush for quick hits to establish anything like the lull and swell of a real rave -- there's no undertow, no rapture, just a randomized string of highs and lows.
In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
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Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
But I think that before embarking on a large randomized controlled trial he first needs to demonstrate that such a trial would even be feasible.
But a related Abbott drug, TriCor, failed to prove its benefits in a large randomized controlled clinical trial.
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"The biggest mistake of ablation was that there wasn't a big randomized study when the technology came out, " he says.
There has been only one study using a large randomized sample, objective measures of well-being, and reports of grown children rather than their parents.
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"For a small randomized rolling subset of users, we will be collecting information ... around what applications you launch and when, " the Facebook spokesman told CNN in an e-mail.
The results are the first from a major randomized clinical trial to indicate that treating an HIV-infected individual can reduce the risk of sexual transmission of HIV to an uninfected partner.
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For one, the groups noted the analysis is a retrospective study, not a prospective, randomized controlled clinical trial, which many regard as a gold standard for ferreting out safety concerns.
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Obviously, these findings are hypothesis-generating only and will have to be tested in a prospective, randomized trial.
"I don't think there is sufficient evidence to justify a widespread change to six-times-a-week dialysis, " says Stanford University nephrologist Glenn Chertow, who is running a big, randomized trial on more frequent in-center treatment.
Despite a number of randomized clinical trials suggesting that EMDR is at least as effective as other commonly accepted therapies for traumatic disorders (i.e. such as post-traumatic stress disorder), it still viewed as a bit of a fringe procedure by many in the mental health field.
We took a hundred people, randomized them, and showed what academic studies have showed: you are not going to lose a ton of weight, but you will probably lose a pound a week for a few weeks.
Again in the 1990s, a bunch of really smart people were exploring the notion of randomized algorithms as a reasonable approach to solving problems.
To really know whether antidepressants have long-term health risks, one would have to do a very, very large study in which 50 percent of the subjects were randomized to receive an antidepressant and the other 50 percent were randomized to take a placebo pill.
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