Develop a test for the hypothesis and test it.

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To prove the importance of the JAK pathway, someone needed to discover a compound to test the hypothesis that inhibiting the JAK enzyme was of value in treating disease.

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It was merely a hypothesis, but it did suggest a programme of research that could be conducted to test the hypothesis.

ECONOMIST: Human evolution

There are broader issues concerning the ways that societies make war, the appropriateness of particular political systems for mass conflict and the efforts to mobilise technical and intellectual resources, which might well have provided a more coherent frame through which to test the hypothesis that the two wars should be treated as one.

ECONOMIST: 20th-century history

To test that hypothesis, Dr Gino and her colleagues ran the experiment again, this time including a test meant to detect self-alienation.

ECONOMIST: Morality

They vote with their test tubes, and they have put their test tubes into a huge number of experiments over this amyloid hypothesis.

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If the hypothesis passes the significance test then it is treated as being true, but a lot can go wrong.

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For the second type of entrepreneur, Spanos advises them to build a prototype and test it out on potential customers in order to determine whether the initial hypothesis about the opportunity is right or should be changed.

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In essence, I believe this was not a failure of the drug or the mechanism but a failure of us as investigators to make sure we had sufficient disease in our population upon which to test our hypothesis--somewhat akin to trying to show one antibiotic is better than another or even a placebo, but selecting a population with no infection!

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