The 29-year-old is recovering from a dislocated shoulder suffered while playing for Sussex last season.
Wigan also suffered an injury worry with Darrell Goulding suffering a dislocated shoulder.
Lions prop Adam Jones was left with a dislocated shoulder after the incident.
New York is also dealing with the loss of captain Ryan Callahan, who is currently sidelined by a dislocated shoulder.
The following day he came off at Keppel Gate and was ruled out of the meeting with a dislocated shoulder.
One was taken to hospital in Bangor with a dislocated shoulder.
The Lions initially did not name a replacement for Shanklin when he was ruled out for 16 weeks with a dislocated shoulder, before eventually turning to Hook.
O'Driscoll last captained the Lions on the ill-fated night in 2005 when he suffered a dislocated shoulder only a minute into the first Test against New Zealand.
The home side suffered their own early injury blow on 13 minutes when prop Craig Mitchell was forced off with a dislocated shoulder, to be replaced by John Yapp.
The Bulls were hit by the late withdrawal of half-backs Paul Deacon and Iestyn Harris with pulled hamstrings and had winger Semi Tadulala taken to hospital with a dislocated shoulder.
Meanwhile Karl Broadhurst's recovery from a dislocated shoulder is going well as he came through the game at Shrewsbury with no ill effects, United's latest signing Nick Chadwick also figured in the game.
Nine people were rescued off Redgate Beach in Torquay following several injuries including a dislocated shoulder and in November two instructors received leg injuries at Anstey's Cove while scouting for new coasteering sites.
Williams has made the Wales team against England after defying the medics by recovering from a dislocated shoulder three weeks ahead of schedule to face the old enemy three weeks before his 34th birthday.
Burger was banned for eight weeks for making contact with the eye area of Lions wing Luke Fitzgerald, while Botha was banned for two weeks for dangerous charging which left Lions prop Adam Jones with a dislocated shoulder.
Two minutes later O'Driscoll, captaining the Lions for the first time since being carried off with a dislocated shoulder in the opening stages of the first Test in New Zealand in 2005, profited from Bowe's break to open his account for the tour.
"He has a badly dislocated shoulder, " said coach Mark Robinson, whose side finished 85-4, a lead of just 60 over Durham, in their second innings.
James partially dislocated a shoulder during Wales' win over the USA while Jones took a blow to the head in the first minute of Wales' 48-15 win.
The man said when the strike began he ran for cover in a nearby cypress forest and dislocated his shoulder when he threw himself on the ground.
Jenkins has a broken cheekbone and Jones dislocated his shoulder.
Mr Fletcher left for South Africa when the local hospital did not have a safety pin for the sling to support his dislocated shoulder.
The Lions also lost Ireland hooker Jerry Flannery, who chipped a bone in training before the tour, Welsh centre Tom Shanklin, who dislocated his shoulder playing for Cardiff Blues, and Ireland scrum-half Tomas O'Leary, who broke his ankle playing for Munster.
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