It was anticipated to be a sure blockbuster but was found to increase deaths and heart disease events in a large clinical trial.
Harriet Millward, of the Alzheimer's Research Trust, said a way to identify people with Alzheimer's before they develop clinical signs of the disease would be a significant breakthrough.
Late last week, Millennium Pharmaceuticals (nasdaq: MLNM - news - people ) disclosed in a regulatory filing that MLN-02, a treatment for Crohn's disease, was effective in a mid-stage clinical trial.
Wyeth, one of the world's largest pharmaceutical companies, created a myostatin-blocking drug and put it into clinical trials for Duchenne muscular dystrophy, a muscle-wasting disease that kills hundreds of men each year before they reach their mid-thirties.
You actually may not have celiac disease or at least you may not have the clinical manifestations of a gluten allergy and you can still have eczema related to celiac disease.
Pharming, a Dutch biotechnology firm, recently began clinical trials for alpha-glucosidase, a product designed to treat Pompe's disease, a metabolic disorder causing fatal degeneration of muscle.
Just before the holiday season, Merck announced that it was halting a major clinical trial with its cardiovascular (CV) disease drug, Tredaptive.
FORBES: Will Merck's Failure With Tredaptive Impact How Drugs Are Approved in Europe?
Remember that the new drugs will have passed clinical trials because they are treatments for a disease, even if they have not been licensed as cognitive enhancers.
's Avastin even when, in a clinical trial she led, the drug failed against the disease.
She stood by Genentech 's Avastin even when, in a clinical trial she led, the drug failed against the disease.
It seemed to work in the deadly and nearly untreatable triple-negative form of the disease but in January 2011 failed in a clinical trial.
Fridman has cofounded a small Massachusetts biotech firm called NeuroHealing Pharmaceuticals that plans to begin a 50-patient clinical trial of an undisclosed Parkinson's disease drug this winter.
The ability to accurately detect a disease is vital for recruiting the right people to clinical trials and for measuring how well a drug may be working.
The Penn Inflammatory Bowel Disease Center has now started enrolling patients in a clinical trial to see if the drugs will be an effective treatment for ulcerative colitis.
Comparative effectiveness research involves running large, statistically robust clinical trials so we can judge how different therapies for a particular disease compare to each other.
FORBES: How Comparative Effectiveness Research Gets Corrupted by Politics
Cytori has also developed a Celution system, which has completed two clinical trials, for applications in cardiovascular disease, wound healing, gastronomical intestinal disorders and urinary incontinence.
FORBES: Human Body's Fat Seen As best Source of Stem Cells For Regenerative Therapies
After all, 50 years after the first clinical trial to cure tuberculosis, the disease still kills almost 3m people a year.
The first application, currently in clinical development, is to treat interstitial cystitis (IC), a painful bladder disease in women that forces them to urinate every 10 minutes.
FORBES: TARIS Biomedical Keeps Delivering Drugs Direct-to-the-Bladder
In a clinical trial conducted in Russia, dimebon improved the ability of patients with Alzheimer's disease on a standardized test used to measure disease severity.
Pfizer had hired Juan Walterspiel, a pediatric infectious disease specialist at Yale Medical School, in 1994 for Trovan's pediatric clinical development.
"If validated in further clinical trials, this would represent a substantially more effective therapy than current treatments for Alzheimer's disease, " he said.
Many eye-vitamin formulations currently on the market are based on research conducted by the National Institutes of Health in a project called Age-Related Eye Disease Study, or AREDS. The first phase of the clinical trial, completed in 2001, found that a specific combination of vitamins C and E, along with beta-carotene and zinc, reduced the risk of age-related macular degeneration by as much as 25%.
In a letter sent to the head of the U.S. Food and Drug Administration's Center for Drug Evaluation and Research, Wolfe outlined a statistical analysis he had done of a 1999 Pfizer-funded test of Celebrex as a preventative for Alzheimer's disease that had just been made available on an industry Web site of clinical trial results.
Disease foundations provide a critical patient perspective and encourage a crisp focus on translating basic science into urgent clinical applications for patients in need.
FORBES: Guest Post: Pfizer Research Boss On Why He's Working With The Cystic Fibrosis Foundation
Today, the Infectious Diseases Society of America, an association of 8, 000 infectious-disease specialists, is announcing a hit list of the six most worrisome germs doctors now face in clinical practice.
The company announced that its first stem cell product to enter clinical trials, PDA-001, recently showed very early and very dramatic results in a few Crohn's disease patients.
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