But gold has been rising so strongly for so long, a big setback now looks overdue.
The decision is also a big setback for the ever-greening strategy employed by big pharma.
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Failure with the obesity drug would be a big setback for Arena but not a fatal one.
If Merck endures a big setback, it may find itself a loser in the next merger wave.
The deal's collapse is a big setback for Germany's financial industry, in which there has been little meaningful consolidation.
Since its creation in 1992, the PTC has expired on three occasions, each a big setback for the wind business.
"The horse had a big setback and then when we tried to get him back, the whole country got flooded, " he said.
A123, in turn, suffered a big setback when Fisker decreased orders.
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Regulators had just dealt a big setback to an experimental Gilead drug, and Martin snapped a shot of his glum-looking research chief, who was in mourning.
Immunogen suffered a big setback in August when the FDA refused to even consider approving the new T-DM1 breast cancer drug its partner Roche is testing based on its technology.
How big a setback do you think it was for relations in this part of the world that he carried out those missile tests in July?
But Daniel McConchie of Americans United for Life says the South Dakota result, in particular, is not as big a setback for pro lifers as it might appear.
With such a crowded calendar, they have the resources to compete in big states like Florida and Michigan and to recover quickly from a setback in Iowa or New Hampshire.
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There is good reason to think that treating Brazil's crisis as merely a temporary setback on the road to recovery is to ignore a potentially more ominous Big Picture - that the event represents another loop in a deflationary spiral that could dampen the world's economic prospects for years to come.
Having said all that, it is a setback for Labour since opposition parties during government crises are meant to win and win big.
He put a brave face on this setback, claiming that he knew how to campaign in a new way, by generating ideas and raising big issues in the televised debates.
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