Almost a decade ago a study demonstrating regression of atherosclerosis with apo A-1 Milano caused tremendous excitement, but the recombinant product has not yet undergone further research or commercial development.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
An even more unusual approach is being explored by Alan Fogelman and his team, who have genetically engineered a tomato to produce a small peptide, 6F, that mimics the action of apo A-1.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
Apo A-1 is thought to be the key HDL component that removes cholesterol from cells.
FORBES: Early Look: New Methods To Enhance Cholesterol Efflux
The surprise was that although men with a copy of the apo E-4 gene made up less than 16% of the group, they accounted for 26% of the heart-disease deaths.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The only disease linked to apo E was a rare type of artery-clogging atherosclerosis.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
"The hope is that we can make a drug that does what apo E-2 does, " he says.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Dr. Roses, however, has a more compelling interest in apo E.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Among both Finns and French, people born with an apo E-2 gene have a four-fold greater likelihood of reaching 100 than those born with an apo E-4, the studies find.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
The ball went left, but Northampton back-row Apo Satala put in a magnificent cover tackle to deny Brian Mujati a try in the corner.
But if a patient has two copies of apo E-4, the odds that the dementia is due to Alzheimer's jumps to 94% from 66%, the Duke scientists say.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Zannis, first discovered 17 years ago that there were three versions of apo E, they found that most people afflicted with a rare type of artery-clogging atherosclerosis had two copies of apo E-2.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
If apo E is truly a marker for longevity, as the studies hint, then "five or 10 years from now, we may have a panel of genes with which you can make a prediction of life expectancy, " Dr. Breslow speculates.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Of course you do not need to be a diver to enjoy the charms of Apo Reef.
Possessing an E-2 or E-3 version of apo certainly isn't a guarantee of avoiding Alzheimer's.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
He is working with a major drug maker to find out why apo E-2 seems to be protective.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Until recently there were two ways to visit Apo: you could shell out for a live-aboard dive safari operating out of the town of Puerto Galera in eastern Mindoro, or out of Coron town in Palawan province south of Mindoro.
Over the same period the productivity of the workforce increased by over 9% a year, according to the Asian Productivity Organisation (APO).
As for cement, Gokongwei expects a glut in three years, but says 34-year-old Apo Cement will remain competitive.
But excited researchers say that apo E is rapidly emerging as the first-found of a set of mysterious genes that roughly determine how long a person will live, provided he or she escapes an "unnatural" death from bacteria and viruses, war, accidents, unhealthy diet, smoking or other environmental happenstance.
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
So, should I open the envelope from Rockefeller, where my apo E status was determined by Dr. Breslow's laboratory as part of a research project?
WSJ: A Gene Gives a Hint Of How Long a Person Might Hope to Live
Also within the atoll-like reef system are picturesque islands that are mid-ocean pit stops for a variety of migrating seabirds, giving twitchers almost as much reason as divers to be excited about Apo Reef.
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