Mice given clozapine showed quadrupled AMPK activity compared to activity measured pre-drug.
鼠给药后显示AMPK活性是使用以前药物的四倍。
Whether local autocrine and paracrine factors within target organs such as the heart modulate AMPK is unknown.
现尚未清楚是否是由心脏等靶器官内的局部自分泌和旁分泌因子调控AMPK。
A role for circulating hormones such as adiponectin and leptin in the activation of AMPK has received recent attention.
近日血循环中的激素如脂联素和瘦素在活化ampk中的作用受到广泛关注。
Treatment of AMPK-DN mice with adiponectin failed to phosphorylate cardiac acetyl-CoA carboxylase as it did in WT mouse heart.
给予AMPK - DN组鼠脂连素处理未能磷酸化心脏乙酰辅酶A羧化酶，而在WT组鼠中可以实现。
The AMPK and ACC Antibody Sampler Kit provides an economical means to investigate energy homeostasis and fatty acid synthesis within the cell.
AMPK和ACC抗体试剂盒为细胞内的能量平衡和脂肪酸合成的研究提供了一种经济有效的方法。
So the basic function of AMPK is to keep the minimal level of cellular ATP and protect the cell from apoptosis induced by low concertration of ATP.
由此可见，AMPK的基本作用是维持细胞内基本的ATP水平、防止细胞由于ATP水平过低而发生细胞凋亡。
In the vascular remodeling, AMPK affects proliferation and energy metabolism of myocardial cells, vascular smooth muscle cells and endothelial cells.
AMPK在心血管重构过程中，对心肌细胞、血管平滑肌细胞、内皮细胞的增殖及能量代谢均有影响。
Thus, MIF modulates the activation of the cardioprotective AMPK pathway during ischaemia, functionally linking inflammation and metabolism in the heart.
这样在缺血时，MIF通过调控有心肌保护作用的AMPK途径的活化情况，功能性的将心脏的炎症跟代谢结合起来。
The team found that inducing ischemia in isolated murine hearts triggered MIF release, leading to AMPK activation and impaired downstream glucose uptake.
研究小 组发现，诱导离体鼠心肌缺血触发了MIF的释放，导致AMPK活化&下游葡萄糖摄取受损。
In a further experiment, the investigators fed untrained mice a substance called AICAR, a synthetic version of AMP that triggers the AMPK switch directly.
在进一步的实验中，研究人员给未经训练的老鼠喂养一种物质叫aicar，一个AMP的合成版可以直接触发ampk转化。
AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis (1).
腺苷酸激活的蛋白激酶(AMPK)是一种在酵母，植物和动物界高度保守的蛋白激酶，它在能量平衡中发挥关键性的作用(1)。
When AMPK detects low levels of ATP in the cell, it works through a different mechanism to increase how much glucose the cell takes in and USES to create ATP.
当细胞内atp含量降低时，AMPK通过一种不同的机制促使葡萄糖进入细胞内氧化利用生成atp。
Furthermore, treatment of AMPK-DN mice with adiponectin reduced MI/R-induced cardiac oxidative and nitrative stress to the same degree as that seen in WT mice.
而且，以脂连素处理AMPK-DN组鼠与WT组鼠同样程度的减轻缺血-再灌注引起的心肌氧化及硝化应激。
AMP-activated protein kinase AMPK is a central component of a protein kinase cascade that plays a pivotal role in the regulation of intracellular energy status.
在调节细胞能量状态的蛋白激酶级联反应中，AMP激活的蛋白激酶（AMPK）是其中枢组成部分。
Adenosine monophosphate-activated protein kinase (AMPK) is considered to be an energy sensor, some energy metabolic hormones can cause changes of AMPK activity.
腺苷酸活化蛋白激酶被认为是机体的能量感受器，一些能量代谢激素可以引起其活性的变化。
Conclusion: Heat stress activated AMPK activity and enhanced the formation of anabolic products and depressed catabolic products in piglets hepatocytes in vitro.
结论：热应激能体外激活仔猪肝细胞AMPK，促进脂质分解代谢产物，抑制脂质合成代谢产物的生成。
Research in rodent models has shown that AMPK activators can lessen the pathologies associated with diabetes, including problems that diabetics have regulating blood sugar.
在啮齿动物模型中使用AMPK活化物可减轻糖尿病相关的病理改变，包括血糖的调控。
Objective: to study the influence of high cell incubating temperature on AMP-activated protein kinase (AMPK) activity and lipid metabolites of piglets hepatocytes in vitro.
目的：研究提高细胞培养温度对仔猪肝细胞一磷酸腺苷激活蛋白激酶(AMPK)活性及脂质代谢产物的影响。
Objective: To investigate the effects of AMP activated protein kinase (AMPK) activation on translocation of glucose transporter 4(GLUT4) and glucose uptake in hypoxic rat myocardium.
目的：探讨心肌缺氧时AMP激活的蛋白激酶（AMPK）激活对葡萄糖转运子4（GL UT4）移位和葡萄糖摄取的作用。
Activated-AMPK plays important roles in increasing glucose uptake in skeletal muscle cells, increasing fatty acid oxidation, improving insulin sensitivity and regulating gene transcription.
AMPK被激活后在增加骨骼肌对葡萄糖摄取、增强胰岛素敏感性、增加脂肪酸氧化以及调节基因转录等方面发挥重要作用。
Activated-AMPK plays important roles in increasing glucose uptake in skeletal muscle cells, increasing fatty acid oxidation, improving insulin sensitivity and regulating gene transcription.
AMPK被激活后在增加骨骼肌对葡萄糖摄取、增强胰岛素敏感性、增加脂肪酸氧化以及调节基因转录等方面发挥重要作用。
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