结论：长循环脂质体是长春新碱的理想载体。
Conclusions: Long-circulating liposome is a good drug delivery system for vincristine.
例如硫酸长春新碱、酒石酸长春瑞宪，NHDC。
Such as Vincristine Sulfate, Vinorelbine Bitartrate, NHDC and Hesperidin Methyl Chalcone.
长春新碱（VCR）为重要和常用抗肿瘤药物之一。
Vincristini sulfas (VCR) is an important common antitumor drug.
目的考察硫酸长春新碱脂质体的体外释放度及其药效。
Objective To investigate the release rate and pharmacodynamics in vitro of of vincristine sulfate liposomes.
目的制备硫酸长春新碱脂质体，建立包封率测定方法。
OBJECTIVE To prepare vincristine sulfate liposomes and to develop a method for determining its entrapment efficiency.
他们发现这种协同作用也发生在脂质体和长春新碱或紫杉醇。
They also found that this synergy occurred with trastuzumab and either paclitaxel or vincristine.
目的优选分离纯化长春花中长春碱和长春新碱的最佳工艺参数。
Objective To optimize the technological parameters of separation and purification of vinblastine and vincristine from Gatharanthus Roseus.
目的：探讨长春新碱治疗慢性原发性血小板减少性紫癫的可行性。
Objective To find out if vincristine can be used to treat the chronic primary thrombocytopenic puripura.
当孩子们服用长春新碱，我们很明显看到他们在学术和神经心理测试上表现变差。
And we've clearly seen children's performance in academic and on neuropsychological tests really be adversely or negatively affected when the child is getting the vincristine.
治疗开始时出现粒细胞减少或血小板减少，并不禁忌用长春新碱治疗。
Thee presence of granulocytopenia or thrombocytopenia at the start of treatment does not contraindicate Vincristin therapy.
治疗开始时出现粒细胞减少或血小板减少，并不禁忌用长春新碱治疗。
The presence of granulocytopenia or thrombocytopenia at the start of treatment does not contraindicate Vincristin therapy.
目的采用主动载药法制备硫酸长春新碱脂质体，考察包封率的影响因素。
OBJECTIVE To prepare vincristine sulfate liposomes by active loading method, and study the influence of different factors on the entrapment efficiency.
结论该工艺简便合理，重复性良好，能得到高纯度的长春碱和长春新碱。
Conclusions The process is simple and reasonable with good reproducibility. It is effective to enrich highly purified vinblastine and vincristine.
探讨长春新碱(VCR)对鼻咽癌cne鄄2 Z细胞增殖和周期的影响。
To investigate the impact of vincristine (VCR) on the cell proliferation and cycle in nasopharyngeal carcinoma cell line CNE-2Z.
目的考察三瓶装硫酸长春新碱脂质体中空白脂质体的物理、化学稳定性。
OBJECTIVE To study the physical and chemical stability of vincristine sulfate-blank liposomes.
如果对长春花的研究不是应用药理学方法的话，长春新碱的发现恐怕还要推迟好多年。
There are more than 100 kinds of alkaloids in vinca plant, including anhydrovinblastine, vinblastine, vincristine and other anti-tumor medicine used in clinic, etc.
如果对长春花的研究不是应用药理学方法的话，长春新碱的发现恐怕还要推迟好多年。
If pharmacological method had not been introduced to the study of vinca rosea, the discovery of vincaleukoblastine would have been postponed by many years.
微管微丝动力学试验证实，S47能抑制微管微丝的聚合，与长春新碱作用机理相同。
Microtubule dynamics test showed that S47 inhibited microtubule polymerization. Vincristine had a mechanism of action similar to that of S47.
所有患儿于放疗后接受长春新碱、环己亚硝脲、顺铂方案化疗，所有患者均未行鞘内化疗。
Chemotherapy was given according to the protocol which consisted of lomustine, cisplatinum and vincristine after radiotherapy, but the patients were not given intrathecal chemotherapy.
目的评价误行鞘内注射长春新碱事件的发生原因、患者神经损害的特点、抢救措施和预后。
Objective To evaluate the reasons for intrathecal administration of vincristine, the characteristics of patients with nerve damage, and the effective rescue measures and outcome prognosis.
长春新碱为抗肿瘤药，仅用于静脉注射，误行鞘内注射可致严重神经损害，并常造成死亡。
Vincristine is an antineoplastic agent for intravenous use only; inadvertent intrathecal administration of vincristine may cause severe neurologic damage, and often is fatal.
目的：研究粉防己碱与长春新碱合用能否逆转人乳腺癌M CF 7多药耐药细胞的抗凋亡作用。
Objective: to study whether the anti-apoptotic action is reversed by tetrandrine in a combination with vincristine in human breast carcinoma MCF-7 multidrug-resistant cells.
据现有资料表明，硫酸长春新碱可单独使用，亦可与其他溶瘤细胞药物合用，以治疗急性白血病……
Information available at present suggests that Oncovin may be useful either alone or in conjunction with other oncolytic drugs for the treatment of acute leukaemias ……
在第二项试验中，来自旧金山Genentech公司的IngridWertz博士和他的同事研究的是包括紫杉醇和长春新碱在内的一大类处方类抗癌药物。
In the second study, Dr. Ingrid Wertz of Genentech in San Francisco and her colleagues focused on certain widely prescribed anti-cancer drugs, including Taxol and vincristine.
在第二项试验中，来自旧金山Genentech公司的IngridWertz博士和他的同事研究的是包括紫杉醇和长春新碱在内的一大类处方类抗癌药物。
In the second study, Dr. Ingrid Wertz of Genentech in San Francisco and her colleagues focused on certain widely prescribed anti-cancer drugs, including Taxol and vincristine.
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